So far in 2025, the Trump administration has cut more than $1 billion in NIH grants. That includes a study on sickle cell disease, a blood disorder that affects roughly 100,000 people in the U.S. According to the CDC, 90% of them are Black. Ali Rogin speaks with Dr. Charity Oyedeji, a Duke University hematologist whose research grant was terminated, to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders
This week, a human rights group in Argentina said a man who disappeared more than 40 years ago under the country’s military dictatorship had been identified and reunited with his sister. But there are concerns that the current government is reversing longstanding policy to continue searching for tens of thousands of citizens who were abducted. Special correspondent Kira Kay reports. PBS News is supported by - https://www.pbs.org/newshour/about/funders
Adoring fans from around the world converged in Thailand this week to celebrate the first birthday of Moo Deng, the baby pygmy hippo who became a social media sensation. John Yang reports. PBS News is supported by - https://www.pbs.org/newshour/about/funders
David Heinemeier Hansson (aka DHH) is a legendary programmer, creator of Ruby on Rails, co-owner & CTO of 37signals that created Basecamp, HEY, & ONCE, and is a NYT-best-selling author (with Jason Fried) of 4 books: REWORK, REMOTE, Getting Real, and It Doesn’t Have To Be Crazy At Work. He is also a race car driver, including a class-winning performance at the 24 hour Le Mans race.
Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep474-sc
See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc.
OUTLINE:
(00:00) – Introduction
(00:58) – Sponsors, Comments, and Reflections
(08:48) – Programming – early days
(26:13) – JavaScript
(36:32) – Google Chrome and DOJ
(44:19) – Ruby programming language
(51:30) – Beautiful code
(1:09:31) – Metaprogramming
(1:12:52) – Dynamic typing
(1:20:10) – Scaling
(1:33:03) – Future of programming
(1:50:34) – Future of AI
(1:56:29) – Vibe coding
(2:05:01) – Rails manifesto: Principles of a great programming language
(2:29:27) – Why managers are useless
(2:38:48) – Small teams
(2:44:55) – Jeff Bezos
(3:00:13) – Why meetings are toxic
(3:07:58) – Case against retirement
(3:15:15) – Hard work
(3:20:53) – Why we left the cloud
(3:24:04) – AWS
(3:33:22) – Owning your own servers
(3:39:35) – Elon Musk
(3:49:17) – Apple
(4:01:03) – Tim Sweeney
(4:12:37) – Fatherhood
(4:38:19) – Racing
(5:05:23) – Cars
(5:10:41) – Programming setup
(5:25:51) – Programming language for beginners
(5:39:09) – Open source
(5:48:01) – WordPress drama
(5:59:18) – Money and happiness
(6:08:11) – Hope
The TSA is finally starting to phase out its decades-old shoe removal policy. We take a look back at the post-9/11 panic that made bare feet in airport security lines a national ritual—and wonder how we went from hypervigilant to oddly indifferent about terrorism. Plus, from the vaults: A classic Spiel from July 17, 2017, revisits Ann Coulter vs. Delta, Day 3. Yes, it somehow made it to Day 3. Produced by Corey Wara
Motley Fool co-founder and CEO Tom Gardner shares some investing insights on the current market, investments to avoid, and a motley array of investing topics:
- Investments to Avoid
- Motley Fool Approach to Investing
- Market Valuations
- Paying for Investment Advice
- Two Big Questions
To watch Tom's message to all members, check out fool.com/message.
CoinDesk speaks with Nicholas Bruckman, the filmmaker behind the documentary 'Minted,' which chronicles the rapid rise and subsequent downturn of the NFT industry. The discussion delves into the origins of Bruckman's interest in NFTs, focusing on prominent digital artists like Mike Winkleman (Beeple) and the early days of NFT hype. Bruckman explains how he captured the meteoric success and challenges faced by artists within the NFT space, navigating both acclaim and skepticism from the artistic community.
'Minted: The Rise (And Fall?) of the NFT' is available on Netflix and other streaming platforms.
President Trump visits Texas a week after the devastating floods. Questions are now being raised whether cuts to FEMA hampered the rescue response. Also, a federal judge orders a stop to indiscriminate immigration raids in Los Angeles. Plus, a new study on antidepressants sheds light on the severity of withdrawal when people come off the medications.
80,000 Bitcoin from 2011 moves sparking conspiracy theories. Elon breaks from Trump, announces America Party with Bitcoin focus. BTC hits $117K all-time high amid political drama and market chaos.
Charlie and Colin dive deep into the $8 billion Bitcoin whale awakening from 2011, conspiracy theories around legal notices, and the dramatic fallout between Elon Musk and Trump. Plus, Bitcoin smashes through $113K as markets defy doomsday predictions.
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NOTES:
• 80,000 Bitcoin moved worth $8.1 billion
• Bitcoin hits new all-time high at $113K
• Funds dormant since 2011 - 13+ years
• Elon announces America Party with Bitcoin focus
• Markets shed 15% earlier this year
• $150B in government waste cuts achieved
Timestamps
00:00 Start
00:52 80k BTC moved
06:03 Message in transaction
16:21 Elon forms political party
22:29 BTC @ $113k
28:28 WW3 with Iran
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