Category: 3-BookTalkDaily

What does the birth of babies whose embryos have gone through genome editing mean—for science and for all of us?

In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences in CRISPR People: The Science and Ethics of Editing Humans (The MIT Press, 2021). Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.

The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next.

Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.

Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch.

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In today’s program, Dr. Paul Steinberg, a psychiatrist and clinical professor at the University of British Columbia, discusses his recently released book Psychoanalysis in Medicine: Applying Psychoanalytic Thought to Contemporary Medical Care (Routledge, 2020). 

In this new volume, Dr. Steinberg offers both theoretical inferences and practical guidance related to the application of psychoanalysis to medical practice. Dr. Steinberg provides insight on, among many other topics, how clinicians’ awareness of their own feelings can aid in the diagnostic process and how a psychoanalytic approach can enrich patient interview.

Alec Kacew is a medical school student at the University of Chicago.

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The arrival in 1532 of a small group of Spanish conquistadores at the Andean town of Cajamarca launched one of the most dramatic – and often misunderstood – events in world history. In Inca Apocalypse: The Spanish Conquest and the Transformation of the Andean World (Oxford UP, 2020), R. Alan Covey draws upon a wealth of new archaeological and archival discoveries to detail the remarkable events that ended one empire and transformed another. From this he builds a new narrative that highlights the apocalyptic mindsets of the two empires and how these shaped the interactions between the Spanish and the Inca. As Covey explains, the Spaniards arrived at a point when the Incan empire was coping with the disruptions caused by a civil war and a devastating pandemic. To the Inca and their neighbors, the Spaniards were yet another disruptive force, one that different groups in the region sought to exploit for their own purposes. The result was twenty years of political infighting and warfare, culminating in the defeat of insurrectionary Spaniards by a force of Incans fighting on behalf of the king of Spain. Though such maneuvering helped preserve a degree of status for the Inca elite, it opened the way for the gradual absorption of the Inca into the Spanish empire in a process that played out over the following century.

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A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer’s disease, and Parkinson’s disease.

Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In his book The Future of Brain Repair: A Realist's Guide to Stem Cell Therapy (MIT Press, 2020), neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer’s disease, Parkinson’s disease, and spinal cord injuries.

Certainly brain disorders are in need of effective treatments. These disorders don’t just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells—and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson’s and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body.

New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair?

You can find more about Jack’s work here and here.

Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch.

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Nutritionists tell you to eat more fish. Environmentalists tell you to eat less fish. Apparently they are both right. It's the same thing with almonds, or quinoa, or a hundred other foods. But is it really incumbent on us as individuals to resolve this looming global catastrophe? From plastic packaging to soil depletion to flatulent cows, we are bombarded with information about the perils of our food system. 

Drawing on years of experience within the food industry, Anthony Warner invites us to reconsider what we think we know. In Ending Hunger: The Quest to Feed the World without Destroying It (Simon and Schuster, 2021), he uncovers the parallels between eating locally and 1930s fascism, promotes the potential for good in genetic modification and dispels the assumption that population growth is at the heart of our planetary woes.

Stephen Pimpare is director of the Public Service & Nonprofit Leadership program and Faculty Fellow at the Carsey School of Public Policy at the University of New Hampshire. He is the author of The New Victorians (New Press, 2004), A People's History of Poverty (New Press, 2008), Ghettos, Tramps & Welfare Queens (Oxford, 2017), and Politics for Social Workers (Columbia, forthcoming 2021).

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Journalists, scholars, politicians, and citizens often assume that calls for secession are political or historical aberrations. Our founding myth is that the Civil War divided an otherwise united nation and we soon reconstructed the United States to form a more perfect union. But Richard Kreitner’s provocative new book,

Break It Up: Secession, Division, and the Secret History of America's Imperfect Union (Little Brown, 2020), argues that “disunion” is the hidden thread in the history of the United States. Kreitner is a contributing writer to The Nation who has also published in The New York Times, Boston Globe, Washington Post, USA Today, Slate, Raritan, and The Baffler.

American politics from colonial times to the present, Break it Up argues, has always included “forces that have conspired to divide it” and Kreitner insists that we get a more nuanced and comprehensive “understanding of both our contentious past and our uncertain future” if we confront that history. Drawing on rich scholarship from multiple disciplines Break It Up argues that the United States has “always been riven by race and religion, cleaved by class and culture, sundered by section, and fragmented by geography.” The United States was always a “tentative proposition” – an “experiment that might fail at any time.” The book insists that asking questions about unity is the “prerequisite for serious discussion about what we Americans want the future to hold for ourselves and this perennially divided union.” Moreover, facing disunion assists in the work of building an inclusive, multiracial democracy capable of combating climate change or racial equality. As the book starkly puts it, the U.S. should either finish the work of Reconstruction or give up on the idea of the “united” states as currently conceived.

Break It Up uses four eras to trace the theme of disunion. “A Vast, Unwieldy Machine” deals with the colonial and Revolutionary periods with Kreitner arguing that resisting a common enemy in the British should not be mistaken for unity. For example, the process of unification was characterized by bitter disagreements over representation and the protection of enslavement in the proposed Constitution. Here, Kreitner reviews some of what is well known in the literature but also smaller (and heated) controversies that may surprise those who think they know the period well. The second era highlights the disagreements in the early Republic over the increase in land (e.g., the Louisiana Purchase) and Aaron Burr’s attempt to break off parts of the country to form an independent Empire. For Hamilton: An American Musical buffs, Kreitner challenges some of Chernow’s assumptions to create a more nuanced understanding of the first Secretary of the Treasury. Kreitner’s third era documents the increasing appetite for disunion in the years before the American Civil War – and the ultimate schism. The fourth period is less defined by chronology. “Return of the Repressed” ranges from Reconstruction to 21st century plans for secession. Kreitner argues that Reconstruction’s failure to resolve fundamental conflicts leave us with a nation perpetually split over race and class.

Susan Liebell is an associate professor of political science at Saint Joseph’s University in Philadelphia. Why Diehard Originalists Aren’t Really Originalists recently appeared in the Washington Post’s Monkey Cage and “Retreat from the Rule of Law: Locke and the Perils of Stand Your Ground” was published in the Journal of Politics (July 2020). Email her comments at sliebell@sju.edu or tweet to @SusanLiebell.

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In the early 1970s, a new wave of public service announcements urged parents to help end an American tradition of child abuse. The message, relayed repeatedly over television and radio, urged abusive parents to seek help. 

Support groups for parents, including Parents Anonymous, proliferated across the country to deal with the seemingly burgeoning crisis. At the same time, an ever-increasing number of abused children were reported to child welfare agencies, due in part to an expansion of mandatory reporting laws and the creation of reporting hotlines across the nation. 

In Abusive Policies: How the American Child Welfare System Lost Its Way (University of North Carolina Press Books, 2020), Mical Raz examines this history of child abuse policy and charts how it changed since the late 1960s, specifically taking into account the frequency with which agencies removed African American children from their homes and placed them in foster care. Highlighting the rise of Parents Anonymous and connecting their activism to the sexual abuse moral panic that swept the country in the 1980s, Raz argues that these panics and policies--as well as biased viewpoints regarding race, class, and gender--played a powerful role shaping perceptions of child abuse. These perceptions were often directly at odds with the available data and disproportionately targeted poor African American families above others.

Claire Clark is a medical educator, historian of medicine, and associate professor in the University of Kentucky’s College of Medicine. She teaches and writes about health behavior in historical context.

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How to understand propaganda art in the post-truth era—and how to create a new kind of emancipatory propaganda art. Propaganda art — whether a depiction of joyous workers in the style of socialist realism or a film directed by Steve Bannon — delivers a message. In Propaganda Art in the 21st Century (MIT Press, 2019), Jonas Staal argues that propaganda does not merely make a political point; it aims to construct reality itself. Political regimes have shaped our world according to their interests and ideology; today, popular mass movements push back by constructing other worlds with their own propaganda.

Jonas Staal speaks to Pierre d'Alancaisez about his proposal for a new model of emancipatory propaganda art — one that acknowledges the relationship between art and power and takes both an aesthetic and a political position in the practice of world-making.

Jonas Staal is a scholar of propaganda and a self-described propaganda artist. He is the founder of the artistic and political organization New World Summit (2012–ongoing) and the campaign New Unions (2016–ongoing). With BAK, basis voor actuele kunst, Utrecht, he co-founded the New World Academy (2013–16). His most recent project Collectivize Facebook exploring legal ways to return the ownership of data in its many forms to the collective ownership of the users of software platforms.

Pierre d’Alancaisez is a contemprary art curator, cultural strategist, researcher. Sometime scientist, financial services professional.

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In his book, Trauma and Race: A Lacanian Study of African American Racial Identity (Baylor UP, 2016), Sheldon George treats an old idea--that African Americans must transform their relationship to the history of slavery and to their identification with race—in an entirely new way.

What follows is a quite truncated encapsulation of the book’s central argument which I will attempt if only because it struck me as a very original use of Lacanian thought. It also produced something I value very much: the development of fresh ideas for this psychoanalyst to ponder.

George argues that owning human property, slaves, offered a surplus of "jouissance" to slave owners. Meanwhile the enslaved, denuded of family, of history and claims to nationality, were often valued solely for muscle mass and fecundity. Psychically emptied--seen only for their capacity to serve the master's needs, and I want to add, also emptying preemptively, and defensively their psychic lives, enslaved people were forbidden access to being, from which flows, following Lacan, crucial early fantasies of a wholeness that must be shattered if one is to become subjectivized. Fantasies of repletion provide a kind of protective “crested shield" with which to endure the rough first brush with the Symbolic.

Living under a racist, white animating Master Signifier, slaves were often absent of the requisite psychic buffering with which to enter the Symbolic without undue suffering. Barred from the rudiments of being and lacking a constructive Master Signifier from which to generate vitalizing associations, the gaze of the enslaved was horrifyingly riveted to the “very lack that is masked in the Lacanian subject,” (p.21). Here George offers an apt description of what the sociologist of slavery, Orlando Patterson, refers to as "social death."

Rather than celebrate the ways in which the burden of “double consciousness” aided African Americans in generating new linguistic vistas, we find no fan of Henry Louis Gates Jr’s “signifying monkey” here. George declares the project of "resignification" as not going far enough, and crucially, as missing the impact of the unconscious on language. Arguing against a powerful trend in African-American studies to value African-American racial identity as such, George boldly declares, “insistences on race perform a rite, an endless repeated act as a means to commemorate the not very memorable encounter that I call the trauma of slavery.” (p.42) How, George asks, can one have an identity based on insult, negation, and injury? Following his argument, the lure of racial pride loses its force majeur. Suddenly we see it as but papering over a potentially productive encounter with lack. And if it is lack that must be faced so as to open the door to a life driven by enlivening, elusive yet worthwhile desire, at what cost is it avoided?

The idea of having love of the race and “the race man” become rather quickly tragic in George’s intellectual hands. Furthermore, embracing the narrative that “we come from slavery”, like Sethe in Toni Morrison's Beloved, (a novel George writes beautifully about in this text) one is quickly cornered, metonymically, by the suffocating relationship between race and enslavement. The need for the space to metaphorize is undeniable.

To learn more about the work of Sheldon George please go here.

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Being a great power almost seems to invite discussion of decline: whether you are declining, what can be done to prevent or arrest it, and what the consequences of decline might ultimately be. The United States has not managed to escape from any of this analysis, but understanding how imperial and hegemonic decline has played out historically often does not inform these discussions. Is the United States an empire, or it better described as a hegemon? What’s the meaningful difference, especially in the current content of the United States’ global position?

Richard Lachmann’s First-Class Passengers on a Sinking Ship: Elite Politics and the Decline of Great Powers (Verso, 2020) explores these questions. Lachmann examines prior explanations of great power decline and finds them wanting for a variety of different reasons. Lachmann instead focuses on a series of factors that first of all enable hegemony, but also the factors that ultimately cause its collapse. Lachmann examines the cause of the Netherlands and the British Empire before examining how these factor are currently at play in the United States.

Zeb Larson is a recent graduate of The Ohio State University with a PhD in History. His research deals with the anti-apartheid movement in the United States. To suggest a recent title or to contact him, please send an e-mail to zeb.larson@gmail.com.

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