Month: June 2017

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Undiscovered - Mouse’s Vineyard

Martha’s Vineyard has a Lyme disease problem. Now a scientist is coming to town with a possible fix: genetically engineered mice.

An island associated with summer rest and relaxation is gaining a reputation for something else: Lyme disease. Martha’s Vineyard has one of the highest rates of Lyme in the country. Now MIT geneticist Kevin Esvelt is coming to the island with a potential long-term fix. The catch: It involves releasing up to a few hundred thousand genetically modified mice onto the island. Are Vineyarders ready?

Kevin Esvelt makes the case for engineered mice, at a public meeting at a Vineyard public library. (Photo: Annie Minoff)

 

Kevin Esvelt takes questions from the Martha’s Vineyard audience. (He’s joined by Dr. Michael Jacobs and Dr. Sam Telford. (Photo: Annie Minoff)

 

Bob, Cheryl, and Spice (the lucky dog who gets a Lyme vaccine). (Photo: Annie Minoff)

 

No lack of tick-repelling options at a Martha’s Vineyard general store. (Photo: Annie Minoff)

 

(Original art by Claire Merchlinsky)

 

GUESTS

Kevin Esvelt, Assistant Professor, MIT Media Lab

 

FOOTNOTES

    Read Kevin Esvelt’s original paper describing the gene drive mechanism in eLife. Less technical descriptions available here via Scientific American, and here via Esvelt’s Sculpting Evolution Group. Watch Kevin’s July 20, 2016 presentation on Martha’s Vineyard (Unfortunately there is no direct link. Search “7.20.16” to find the video, titled “Preventing Tick-Borne Disease.”) Listen to Kevin Esvelt talk about gene drive on Science Friday. Read about Oxitec’s proposed mosquito trial in Key West, and watch the public meeting excerpted in this episode. Learn more about Kevin’s lab, the Sculpting Evolution Group. Looking for more information about Lyme disease? Here are resources from the CDC.

CREDITS

This episode of Undiscovered was reported and produced by Annie Minoff and Elah Feder. Editing by Christopher Intagliata. Fact-checking help by Michelle Harris. Original music by Daniel Peterschmidt. Our theme music is by I am Robot and Proud. Art for this episode by Claire Merchlinsky. Thanks to Science Friday’s Danielle Dana, Christian Skotte, Brandon Echter, and Rachel Bouton.

 

Special thanks to Joanna Buchthal, Bob Rosenbaum, Dick Johnson, and Sam Telford.

 

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The Gist - The Rise and Reign of Unruly Women

Anne Helen Petersen has made a career on the rigorous, deep, academic study of celebrity culture. In her new book Too Fat, Too Slutty, Too Loud, Petersen explores the rise of norm-breaking women such as Lena Dunham and Serena Williams and what their ascendency can tell us about the political moment we’re living in. Petersen’s day job is senior culture writer at BuzzFeed.

Also, the Supreme Court makes a surprise ruling, and the Congressional Budget Office makes an unsurprising report.

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Start the Week - Power: Fleet Street and Whitehall

On Start the Week Tom Sutcliffe talks to the former Conservative MP and last Governor of Hong Kong, Chris Patten, on the eve of the 20th anniversary of the handover of Hong Kong from Britain to China. In a candid memoir Patten looks back at his political life. He lost his seat in the 1992 election, despite the Sun newspaper claiming the Tory landslide with the headline, "It's The Sun Wot Won It". James Graham's new play goes back to the birth of this ruthless 'red top' tabloid, when a young and rebellious Rupert Murdoch burst on to Fleet Street, to launch a newspaper devoted to giving the people what they want. Fleet Street is no more and following this month's general election some critics have questioned the continuing influence of the mainstream media. Kerry-Anne Mendoza is the Editor-in-chief of the left-wing political blog, The Canary, and believes new forms of media online are disrupting the status quo in the UK. Baroness Tessa Blackstone was regarded as a kaftaned radical in the 1970s by the Whitehall establishment when she was part of a review of Central Policy which challenged the very workings of Britain's powerful diplomatic corps. Producer: Katy Hickman

Image: The Sun daily newspaper on June 14, 2016, with a headline urging readers to vote 'Leave' in the June 23 EU referendum. Credit: DANIEL SORABJI /AFP/ Getty Images.