In the mornings, Sonia Vallabh and Eric Minikel's first job is to get their two garrulous kids awake, fed and out the door to daycare and kindergarten. They then reconvene at the office and turn their focus to their all-consuming mission: to cure, treat, or prevent genetic prion disease.
Prions are self-replicating proteins that can cause fatal brain disease. For a decade, Sonia Vallabh has been living with the knowledge that she has a genetic mutation that will likely cause in her the same disease that claimed her mother's life in 2010. Upon discovering she had the mutation, Sonia and her husband made a massive pivot: They went from careers in law and urban planning to earning their Ph.D.s, and founding a prion research lab at the Broad Institute of MIT and Harvard. On today's episode, Sonia and Eric talk with Short Wave's Gabriel Spitzer about what it's like to run a lab with one's spouse, cope with the ticking clock in Sonia's genes, and find hope in a bleak diagnosis.
The big three healthcare companies aren’t paying much attention to Mark Cuban’s new health care venture, Cost Plus Drugs. But their margins could mean a huge opportunity for the new start-up. Chris Hill caught up with Cuban to discuss:
- Why he’s able to sell a leukemia drug for thousands of dollars less than competitors - Stocks he bought during the pandemic - Advice for potential NFL owner Jeff Bezos
Since the Covid-19 pandemic began, scientists studying the virus have become targets of online harassment, and more recently, death threats. Roland speaks to Dr Angela Rasmussen, virologist at the Vaccine and Infectious Disease Organization at the University of Saskatchewan, about her experiences.
Spyros Lytras, PhD candidate at the University of Glasgow, talks Roland through the evolutionary history of the virus that causes Covid-19 and how there isn’t just one ancestor, but several.
Anti-Asian sentiment has seen a big increase since the pandemic. Dr Qian He, Postdoctoral Research Associate at Princeton University, looked into how US-China relations have influenced how Americans view Chinese today.
And we hear from scientists on board the RRS Discovery, which is currently located near St Helena and Ascension Island, surveying the health of the surrounding ocean. On board documentary filmmaker Lawrence Eagling talks to Shona Murray, pelagic ecologist from the University of Western Australia, and Gareth Flint, mechanical engineer at British Antarctic Survey, about their work and findings.
Why don’t we fall out of bed when we’re asleep? That’s the question that’s been keeping CrowdScience listener Isaac in Ghana awake, and presenter Alex Lathbridge is determined to settle down with some experts and find an answer.
Once our sleep experts are bedded in, we’ll also be wondering why some people laugh in their sleep, why others snore and how some people can remember their dreams.
And Alex takes a trip to the zoo to meet some animals that have very different sleep patterns to humans. It’s his dream assignment.
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“The Breakdown” is written, produced by and features Nathaniel Whittemore aka NLW, with editing by Rob Mitchell and research by Scott Hill. Jared Schwartz is our executive producer and our theme music is “Countdown” by Neon Beach. Music behind our sponsors today is "Back To The End" by Strength To Last. Image credit: C.J. Burton/Getty Images, modified by CoinDesk. Join the discussion at discord.gg/VrKRrfKCz8.
After decades as America’s booming industry, tens of thousands of tech workers have been laid off in November alone. Is the venture-capital, low-interest-rate wind leaving the sails temporary or is this the end of the hunt for “the next big thing?”
Guest: Timothy B. Lee, reporter for Full Stack Economics covering labor markets, technology, and housing.
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Thanksgiving is probably the most celebrated meal of the year. But for a lot of home cooks or new cooks, or would-be cooks-- it's also the most daunting.
Host Michel Martin speaks with Melissa Clark, a food writer for the New York Times. Clark shares a super easy Thanksgiving dinner recipe from her latest cookbook, Dinner in One: Exceptional and Easy One Pan Meals. And the cooking pros featured in our In A Pinch offer tips on pulling off a no-hassle holiday meal.
We riff on the artisanal race science of Caroline Ellison, CEO of Alameda Research, the crypto hedge fund linked to FTX. Then we introduce you to the Harman Ready Care system, yet another of the wonderful innovations on the market contributing, in its own incremental way, to improving the world today.
••• Introducing HARMAN Ready Care: Detects Driver Behaviors and Assists via Context-Aware Interventions for Safer and Smarter Drives https://www.businesswire.com/news/home/20220914005609/en/Introducing-HARMAN-Ready-Care-Detects-Driver-Behaviors-and-Assists-via-Context-Aware-Interventions-for-Safer-and-Smarter-Drives
••• Data Driven: Truckers, Technology, and the New Workplace Surveillance https://press.princeton.edu/books/hardcover/9780691175300/data-driven
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Hosted by Jathan Sadowski (www.twitter.com/jathansadowski) and Edward Ongweso Jr. (www.twitter.com/bigblackjacobin). Production / Music by Jereme Brown (www.twitter.com/braunestahl)