Short Wave - A Deeply Personal Race Against A Fatal Brain Disease

In the mornings, Sonia Vallabh and Eric Minikel's first job is to get their two garrulous kids awake, fed and out the door to daycare and kindergarten. They then reconvene at the office and turn their focus to their all-consuming mission: to cure, treat, or prevent genetic prion disease.

Prions are self-replicating proteins that can cause fatal brain disease. For a decade, Sonia Vallabh has been living with the knowledge that she has a genetic mutation that will likely cause in her the same disease that claimed her mother's life in 2010. Upon discovering she had the mutation, Sonia and her husband made a massive pivot: They went from careers in law and urban planning to earning their Ph.D.s, and founding a prion research lab at the Broad Institute of MIT and Harvard. On today's episode, Sonia and Eric talk with Short Wave's Gabriel Spitzer about what it's like to run a lab with one's spouse, cope with the ticking clock in Sonia's genes, and find hope in a bleak diagnosis.

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It Could Happen Here - Inside Twitter’s Soul

Robert and the gang discuss the comments to a single Elon Musk tweet, which is more revealing and culturally important than you might guess.

See omnystudio.com/listener for privacy information.

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Motley Fool Money - Mark Cuban on Drugs, Investing, and Advice for Jeff Bezos

The big three healthcare companies aren’t paying much attention to Mark Cuban’s new health care venture, Cost Plus Drugs. But their margins could mean a huge opportunity for the new start-up. Chris Hill caught up with Cuban to discuss:

- Why he’s able to sell a leukemia drug for thousands of dollars less than competitors - Stocks he bought during the pandemic - Advice for potential NFL owner Jeff Bezos

To check out Mark's new business go to www.CostPlusDrugs.com

Companies mentioned: WBA, CVS, NFLX, LYV, LVS, AMZN

Host: Chris Hill Guest: Mark Cuban Producer: Ricky Mulvey Engineers: Dan Boyd, Austin Morgan, Tim Sparks

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Unexpected Elements - Online harassment of Covid scientists

Since the Covid-19 pandemic began, scientists studying the virus have become targets of online harassment, and more recently, death threats. Roland speaks to Dr Angela Rasmussen, virologist at the Vaccine and Infectious Disease Organization at the University of Saskatchewan, about her experiences.

Spyros Lytras, PhD candidate at the University of Glasgow, talks Roland through the evolutionary history of the virus that causes Covid-19 and how there isn’t just one ancestor, but several.

Anti-Asian sentiment has seen a big increase since the pandemic. Dr Qian He, Postdoctoral Research Associate at Princeton University, looked into how US-China relations have influenced how Americans view Chinese today.

And we hear from scientists on board the RRS Discovery, which is currently located near St Helena and Ascension Island, surveying the health of the surrounding ocean. On board documentary filmmaker Lawrence Eagling talks to Shona Murray, pelagic ecologist from the University of Western Australia, and Gareth Flint, mechanical engineer at British Antarctic Survey, about their work and findings.

Why don’t we fall out of bed when we’re asleep? That’s the question that’s been keeping CrowdScience listener Isaac in Ghana awake, and presenter Alex Lathbridge is determined to settle down with some experts and find an answer.

Once our sleep experts are bedded in, we’ll also be wondering why some people laugh in their sleep, why others snore and how some people can remember their dreams.

And Alex takes a trip to the zoo to meet some animals that have very different sleep patterns to humans. It’s his dream assignment.

(Image credit: Getty Images)

CoinDesk Podcast Network - BREAKDOWN: Okay Proof of Reserves, But for Real This Time?

Numerous exchanges committed to proof of reserves after FTX, but is it enough?

This episode is sponsored by Nexo.io, Circle and Kraken.

On this edition of “Long Reads Sunday,” NLW reads Nic Carter’s newest “Let’s Actually Commit to Proofs of Reserve This Time, Okay?

-

Nexo Pro allows you to trade on the spot and futures markets with a 50% discount on fees. You always get the best possible prices from all the available liquidity sources and can earn interest or borrow funds as you wait for your next trade. Get started today on pro.nexo.io.

-

Circle, the sole issuer of the trusted and reliable stablecoin USDC, is our sponsor for today’s show. USDC is a fast, cost-effective solution for global payments at internet speeds. Learn how businesses are taking advantage of these opportunities at Circle’s USDC Hub for Businesses.

-

Kraken, the secure, trusted digital asset exchange, is our sponsor for today’s show. Kraken makes it easy to instantly buy 185+ cryptocurrencies with fast, flexible funding options. You’re covered by industry-leading security and award-winning Client Engagement, available 24/7. Sign up and trade today at kraken.com.

-

“The Breakdown” is written, produced by and features Nathaniel Whittemore aka NLW, with editing by Rob Mitchell and research by Scott Hill. Jared Schwartz is our executive producer and our theme music is “Countdown” by Neon Beach. Music behind our sponsors today is "Back To The End" by Strength To Last. Image credit: C.J. Burton/Getty Images, modified by CoinDesk. Join the discussion at discord.gg/VrKRrfKCz8.



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Everything Everywhere Daily - The FIFA World Cup

In 1872 the first international football match took place between England and Scotland. 

Since then, international football has been at the apex of world sport. 

Starting in 1930, a quadrennial competition has been held where the greatest national teams competed to determine the world champion.

Learn more about the FIFA World Cup, its history, and the controversy surrounding it on this episode of Everything Everywhere Daily.



Subscribe to the podcast! 

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Associate Producers: Peter Bennett & Thor Thomsen

 

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What Next | Daily News and Analysis - TBD | The End of the Tech Boom

After decades as America’s booming industry, tens of thousands of tech workers have been laid off in November alone. Is the venture-capital, low-interest-rate wind leaving the sails temporary or is this the end of the hunt for “the next big thing?”


Guest: Timothy B. Lee, reporter for Full Stack Economics covering labor markets, technology, and housing.


Host: Lizzie O’Leary


If you enjoy this show, please consider signing up for Slate Plus. Slate Plus members get benefits like zero ads on any Slate podcast, bonus episodes of shows like Slow Burn and Dear Prudence—and you’ll be supporting the work we do here on What Next TBD. Sign up now at slate.com/whatnextplus to help support our work.

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Consider This from NPR - How to Cook a Faster, Easier Thanksgiving Dinner

Thanksgiving is probably the most celebrated meal of the year. But for a lot of home cooks or new cooks, or would-be cooks-- it's also the most daunting.

But what if there was a much easier approach to Thanksgiving for cooks who don't have the time - or frankly, the patience? What if you could make Thanksgiving dinner in a few hours with one pot and one pan? No kidding!

Host Michel Martin speaks with Melissa Clark, a food writer for the New York Times. Clark shares a super easy Thanksgiving dinner recipe from her latest cookbook, Dinner in One: Exceptional and Easy One Pan Meals. And the cooking pros featured in our In A Pinch offer tips on pulling off a no-hassle holiday meal.

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This Machine Kills - Patreon Preview – 210. worldoptimization.tumblr

We riff on the artisanal race science of Caroline Ellison, CEO of Alameda Research, the crypto hedge fund linked to FTX. Then we introduce you to the Harman Ready Care system, yet another of the wonderful innovations on the market contributing, in its own incremental way, to improving the world today. ••• Introducing HARMAN Ready Care: Detects Driver Behaviors and Assists via Context-Aware Interventions for Safer and Smarter Drives https://www.businesswire.com/news/home/20220914005609/en/Introducing-HARMAN-Ready-Care-Detects-Driver-Behaviors-and-Assists-via-Context-Aware-Interventions-for-Safer-and-Smarter-Drives ••• Data Driven: Truckers, Technology, and the New Workplace Surveillance https://press.princeton.edu/books/hardcover/9780691175300/data-driven Subscribe to hear more analysis and commentary in our premium episodes every week! https://www.patreon.com/thismachinekills Grab TMK gear: https://www.bonfire.com/store/this-machine-kills-podcast/ Hosted by Jathan Sadowski (www.twitter.com/jathansadowski) and Edward Ongweso Jr. (www.twitter.com/bigblackjacobin). Production / Music by Jereme Brown (www.twitter.com/braunestahl)