Month: November 2022

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Serious Inquiries Only - SIO347: Does Microdosing Work? Recorded LIVE at QED!

Science person and apparent druggy drug person Lindsey Osterman took us through what the science says on microdosing!

Links: Cavanna et al (2022) Microdosing with Psilocybin Mushrooms, Lea et al (2020) Microdosing Psychedelics: Motivations, Subjective Effects and Harm Reduction, Goldberg et al (2021) Post-Acute Psychological Effects of Classical Serotonergic Psychedelics, Yu et al (2021)  Psilocybin for End-of-Life Anxiety Symptoms

Mason et al (2021)  Spontaneous and Deliberate Creative Cognition During and After Psilocybin Exposure

Amoroso & Workman (2016)  Treating PTSD with MDMA-Assisted Psychotherapy

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Short Wave - Killer Proteins: The Science Of Prions

Prions are biological anomalies – self-replicating, not-alive little particles that can misfold into an unstoppable juggernaut of fatal disease. Prions don't contain genes, and yet they make more of themselves. That has forced scientists to rethink the "central dogma" of molecular biology: that biological information is always passed on through genes. The journey to discovering, describing, and ultimately understanding how prions work began with a medical mystery in a remote part of New Guinea in the 1950s. The indigenous Fore people were experiencing a horrific epidemic of rapid brain-wasting disease. The illness was claiming otherwise healthy people, often taking their lives within months of diagnosis. Solving the puzzle would help unlock one of the more remarkable discoveries in late-20th-century medicine, and introduce the world to a rare but potent new kind of pathogen. For the first episode in a series of three about prion disease, Short Wave's Gabriel Spitzer shares the science behind these proteins with Emily Kwong, and explains why prions keep him awake at night.

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NPR's Book of the Day - ‘Gods of Soccer’ celebrates 100 of the world’s best players

Men in Blazers' Roger Bennett knows football – or soccer, as Americans call it. His new book, Gods of Soccer, lists 100 players who've made their mark on the sport one way or another. He tells Mary Louise Kelly about how he managed to compile that list, and why the book delves into the origin stories and cultural impact of a wide range of players – not just the Ronaldo and Messi household names, but the lesser-known figures who are iconic in their own right.
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It Could Happen Here - The Socialists Who Want 500,000 More Cops Part 1: Lying With Statistics

We look at a recent call by two Harvard academics, one of whom is on the editorial board of Jacobin, for 500,000 more cops to end mass incarceration

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the memory palace - Episode 201: One Fruit

The Memory Palace is a proud member of Radiotopia from PRX.

Music

  • Strength of a Young Man by Vernon Field

  • Wave I by Elori Saxl

  • Rearranging Furniture from Gabriel Yared’s score to By the Sea

  • Falling Forever and Ever by Ricky Eat Acid

  • Muff Gets a Share from Joel P West’s score to Band of Robbers

Notes

  • By far the most fun I had researching this was reading Kaori O’Conner’s Pineapple: A Global History. Really a lovely little book.
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Planet Money - Sam Bankman-Fried and the fall of a crypto empire

Sam Bankman-Fried built a reputation as the one reliable crypto bro. But within the span of days, his empire came crashing down. What the rise and fall of crypto's 30-year-old elder statesman says about the story of crypto so far.

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Consider This from NPR - What Happens To The Investigations Involving Now-Candidate Trump?

Former President Trump is launching his 2024 campaign with a cloud of legal issues hanging over his head. They include the federal investigation into the January 6 insurrection at the U.S. Capitol, another into the top secret documents he kept at Mar-a-Lago and a criminal tax fraud trial in New York.

University of Michigan Law Professor Barbara McQuade, a former U.S. Attorney, explains how his status as a candidate might weigh on those investigations.

And NPR media correspondent David Folkenflik explains another development since Trump's last campaign: the conservative media properties run by Rupert Murdoch appear to have cooled on the former president.

In participating regions, you'll also hear a local news segment to help you make sense of what's going on in your community.

Email us at considerthis@npr.org.

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The Gist - Implicating Trump Under Oath

Gordon Sondland was Ambassador to the EU, which eventually led to his testimony during the first impeachment proceedings against Donald Trump. Sondland confirmed some elements of the quid-pro-quo, backed up other parts of Trump’s narrative, and was soon fired for his participation. His new book is The Envoy: Mastering the Art of Diplomacy with Trump and the World. Plus, the aforementioned Donald Trump has just announced he’ll run once more for President, Mike has the full breakdown of news, norms, psychology, and turkey prices.

Produced by Joel Patterson and Corey Wara

Email us at thegist@mikepesca.com

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Reset with Sasha-Ann Simons - Sen. Duckworth Lays Out Priorities For Lame Duck Session, 118th Congress

Duckworth plans to push for an assault weapons ban, stronger benefits for U.S. veterans and their families, water protections and more when the next Congress is sworn in in January, and she says there’s a lot of important work to do before that during the lame duck session. Reset talks to newly-reelected U.S. Senator Tammy Duckworth about those priorities and why she believes bipartisanship is still a possibility, even with a divided legislative branch.