Author: BBC World Service

One CrowdScience listener finds herself unconcerned about much of the world’s problems, it leaves her wondering: am I a psychopath?

Inspired by a previous episode on empathy, this listener asked is it true that psychopaths don’t empathise and what are the character traits of psychopathy?

Marnie Chesterton talks with a diagnosed pro-social psychopath to find out.

She also pays a visit to the Netherlands Institute for Neuroscience and gets into an MRI scanner to discover what is happening in her brain when she empathises.

Studies suggest around 1 percent of the general population exhibit traits associated with psychopathy and that rises to 3-4 percent in the world of business. But is this really the case?

Why is there so much stigma associated with psychopathy and do psychopaths even exist or is it just a convenient term to label those whose emotional range sits outside of the “norm”?

Presented by Marnie Chesterton and produced by Caroline Steel for the BBC World Service.

Guests: Julia Shaw Jim Fallon Valeria Gazzola Kalliopi Ioumpa

[Image credit: Getty Images]

Back in November it was announced that an AI company called DeepMind had essentially cracked the problem of protein folding – that is they had managed to successfully predict the 3D structures of complex biochemical molecules by only knowing the 2D sequence of amino acids from which they are made.

They are not the only team to use machine learning to approach the vast amounts of data involved. But last week, they released the source code and methodology behind their so called AlphaFold2 tool. Today, they are publishing via a paper in the journal Nature, a simply huge database of predicted structures including most of the human proteome and 20 other model species such as yes, mice. The possibilities for any biochemists are very exciting.

As DeepMind CEO Demis Hassabis tells Roland Pease, they partnered with the European Molecular Biology Laboratory to make over 350,000 protein predictions available to researchers around the world free of charge and open sourced. Dr Benjamin Perry of the Drugs for Neglected Diseases Initiative told us how it may help in the search for urgently needed drugs for difficult diseases such as Chagas disease. Prof John McGeehan of the Centre for Enzyme Innovation at Portsmouth University in the UK is on the search for enzymes that might be used to digest otherwise pollutant plastics. He received results (that would have taken years using more traditional methods) back from the AlphaFold team in just a couple of days.

Prof Julia Gog of Cambridge University is a biomathematician who has been modelling Covid epidemiology and behaviour. In a recent paper in Royal Society Open Science, she and colleagues wonder whether the vaccination strategy of jabbing the most vulnerable in a population first, rather than the most gregarious or mobile, is necessarily the optimal way to protect them. Should nations still at an early stage in vaccine rollout consider her model?

And did you know that elephants can hear things up to a kilometre away through their feet? And that sometimes they communicate by bellowing and rumbling such the ground shakes? Dr Beth Mortimer of Oxford University has been planting seismic detectors in savannah in Kenya to see if they can tap into the elephant messaging network, to possibly help conservationists track their movements.

Image: Protein folding Credit: Nicolas_/iStock/Getty Images

Presenter: Roland Pease Producers: Alex Mansfield and Samara Linton

Anyone who has ever taken the Christmas lights out of the cupboard, only to discover they’re hopelessly tangled, will sympathise with this week’s listener Eric. He has a 45m garden hose that always seems to snarl up and snag when he waters his garden, and he wonders what he’s doing wrong?

Marnie starts by discovering the important difference between tangles and knots, as she scales a cliff with an experienced climber who explains the way you tie rope is a matter of life and death.

Physicists are also fascinated in how string becomes jumbled up and one man has even won an IgNobel award for his work in this field. Doug E Smith discovered that if you put a piece of string in a box then spin it around, its length, thickness and how long you shake the box for, all determine whether it will tie itself up. Not only that, the more the string becomes twisted, the more likely it is to cross over itself and become impossible to untangle.

While tangles might be annoying in hair or cables, they’re also a fundamental part of human life. Our DNA is constantly folding itself to fit inside tiny spaces – there are two metres of the stuff inside every cell, where it’s packed down tightly, before it must untangle and duplicate for those cells to divide. It does this with the help of specific enzymes, and when the process goes wrong it leads to cell death. But scientists are also studying molecular tangles that might benefit us humans, and creating nano-sized knots that can be turned into nets or meshes with incredible properties. Producer: Ilan Goodman Presenter: Marnie Chesterton

This week the UK parliament voted to accept the Government’s continued cap on Official Development Aid. This disappointed many researchers around the world, funded directly and indirectly through various scientific funding structures enabling international collaboration on some of the global challenges facing all of us. These funding mechanisms make for a small fraction of the overall amount, but they have been hit hard, with many projects closing altogether.

There had been hope amongst the scientific community that the cap – from 0.7% down to 0.5% of the UK’s Gross Domestic Income – might have been in place just for a year. But it seems like the criteria set to judge when the level of aid might rise again imply that it is unlikely to happen for several years at the earliest.

What, asks Science in Action, does that mean to the world of scientific collaboration on such topics as climate change, contagious disease, and emergency planning?

Researchers Chris Trisos and Jenni Barclay, with journalist Robin Bisson of Research Professional News, update us on the story.

In Zambia, where covid testing remains scarce, a project run by Boston University’s Christopher Gill has been estimating the prevalence of covid in the capital Lusaka by taking nasal swab samples from the noses of around one in five of those recently deceased, in the morgue of a major hospital. Tantalisingly, his team have seen over the last few months a sharp rise in cases to the extent that in June, nearly 90 percent of the cadavers tested positive for covid. But as Chris describes, unrelated to the UK cuts, their funding has now run out, so where the graph leads from here we may not learn for a long time.

Presented by Roland Pease Produced by Alex Mansfield.

(Image: Getty Images)

Standing takes less energy than walking, so why does it feel more tiring? At least, it does for CrowdScience listener Nina. She can march for hours without getting tired, but her legs and feet get achy after just a short time standing still.

It’s one of three walking-themed questions CrowdScience is tackling this week. Taking inspiration from our active listeners, Marnie Chesterton walks up a hill with Caroline Williams, author of a new book about why humans are designed to move. We find out how our whole system – body and brain – works better when we’re walking, compared to standing still. We’re probably set up this way because of our evolutionary history: hunting and gathering needed us to be ‘cognitively engaged endurance athletes’.

We stop for a break.. but is it true that we shouldn’t sit down to rest during a walk? Our listener Sarah is a keen hillwalker but likes to take the weight off her feet every now and again. Her hillwalking friends disapprove, saying she should rest on her feet. Is this a myth CrowdScience can bust?

And finally a question from listener Matteo: is walking or running better for your health? Numerous studies show significant benefits to both forms of exercise, but in the end, the best kind of exercise is the one you’re motivated to do.

With Caroline Williams, Dr François-Xavier Li, Professor Dick Greene and Professor Duck-Chul Lee.

Scientists say the record-breaking Pacific North-West heatwave of recent weeks must have been caused by human induced climate change, but as Geert Jan van Oldenborgh explains to Roland Pease, despite a herculean effort to analyse the event in just a week, the precise mechanism to cause such an extreme and sudden event is so far bewildering climate modellers, exceeding even worst expectations.

Looking to the skies, Rosita Kokotanekova of the European Southern Observatory and colleagues have been getting excited about the discovery of a comet maybe twice as large as any observed before. Being so big, it has been spotted much further out from the sun and – if the best telescopes can be convinced to join the fun – will provide astronomers a chance to observe the core of the comet before the solar heat induces a gaseous coma to form as it nears the point in its orbit closest to the sun. It will be around for the next decade before continuing its several million year journey around our mutual star.

But it won’t get terribly close to earth, at least not as close as lumps of an asteroid that fell onto a driveway in the UK earlier this year. Dr Ashley King of the UK’s Natural History Museum is leading a consortium of scientists (benefitting from a rapid research grant by the UK’s STFC) who have now officially classified it and named it. The Winchcombe meteorite is a CM carbonaceous chondrite, meaning it represents the unspoilt early building blocks of the solar system. Falling like 4.5 billion year old leftover celestial lego, only a few are known around the world but perhaps none have been in scientists hands in such a short period of time, continuing its pristine survival.

Dr Pablo Tsukayama has published a preprint paper announcing a new variant of interest in the ongoing evolution of the SARS-CoV2 virus. Now named by the WHO as the Lambda variant, it seems it has driven the pandemic for much of this year in Peru – as much as 80% of cases – and large fractions of the outbreak elsewhere in South America. But as Pablo suggests, the reason we don’t know as much about it as for example the Alpha or Delta variants is likely because it hasn’t thus far affected the countries best equipped to do the analysis. Maybe that could change.

Image: Wildfires in Lytton, British Columbia Credit: ProPics Canada Media Ltd/Getty Images

Presenter: Roland Pease Producer: Alex Mansfield