Science In Action - Perseverance approaches Mars

On 18th February the Perseverance rover should land on Mars. Katie Stack-Morgan of NASA’s Jet Propulsion Lab tells Roland Pease about the technological advances that mean that the spacecraft should be able to land in Jezero Crater. Imperial College geologist Sanjeev Gupta discusses what this crater can reveal about the history of life on the red planet.

After months of negotiations, and weeks of work on the ground, a team brought together by the World Health Organisation has just concluded its first attempts to find out the origins of SARS-Cov2 in Wuhan. Peter Daszak, who has worked closely with Chinese virologists in the past, briefed Roland Pease on what had been discovered.

The South African government has announced that it will not be rolling out the Astra Zeneca Covid vaccine as it appears it is not very effective against the dominant strain in the country. Helen Rees, of Witwatersrand University and a member of South Africa’s Health Products Regulatory Authority, explains that the ‘ban’ is an overstatement.

At least 35 people died in a flood disaster in the Himalayan state of Uttarakhand in India on February 6th. The details are still unclear, but the trigger seems to be associated with a glacier overhanging an upstream lake in the steep valley. Rupert Stuart-Smith of Oxford University, who has just published an analysis of a glacier melting disaster in waiting in the Andes, talks about the impacts of climate change on the stability of mountain glaciers.

(Image: An illustration of NASA’s Perseverance rover landing on Mars. Credit NASA/JPL-Caltech)

Unexpected Elements - Mixing Covid vaccines

A new trial is about to start in the UK, seeing if different vaccines can be mixed and matched in a two-dose schedule, and whether the timing matters. Governments want to know the answer as vaccines are in short supply. Oxford University’s Matthew Snape takes Roland Pease through the thinking.

Despite the numbers of vaccines being approved for use we still need treatments for Covid-19. A team at the University of North Carolina is upgrading the kind of manufactured antibodies that have been used to treat patients during the pandemic, monoclonal antibodies. Lisa Gralinski explains how they are designing souped-up antibodies that’ll neutralise not just SARS-CoV-2, but a whole range of coronaviruses.

Before global warming, the big ecological worry that exercised environmentalists was acid rain. We’d routinely see pictures of forests across the world dying because of the acid soaking they’d had poisoning the soil. In a way, this has been one of environmental activism’s success stories. The culprit was sulphur in coal and in forecourt fuels – which could be removed, with immediate effect on air quality. But biogeochemist Tobias Goldhammer of the Leibniz Institute in Berlin and colleagues have found that sulphur, from other sources, is still polluting water courses.

There’s been debate over when and where dogs became man’s best friend. Geoff Marsh reports on new research from archaeology and genetics that puts the time at around 20,000 years ago and the place as Siberia.

Could being happier help us fight infectious disease?

As the world embarks on a mass vaccination programme to protect populations from Covid-19, Crowdscience asks whether our mood has any impact on our immune systems. In other words, could being happier help us fight infectious diseases? Marnie Chesterton explores how our mental wellbeing can impact our physical health and hears that stress and anxiety make it harder for our natural defence systems to kick in – a field known as psychoneuroimmunology. Professor Kavita Vedhara from the University of Nottingham explains flu jabs are less successful in patients with chronic stress.

So scientists are coming up with non-pharmacological ways to improve vaccine efficiency. We investigate the idea that watching a short feel-good video before receiving the inoculation could lead to increased production of antibodies to a virus. And talk to Professor Richard Davidson who says mindfulness reduces stress and makes vaccines more effective.

World Book Club - Bill Bryson: Notes from a Small Island

This month World Book Club discusses Bill Bryson’s hugely acclaimed travelogue Notes from a Small Island with the author and his readers around the world. After two decades as a resident of the United Kingdom, Bryson took what he thought might be a last affectionate trip around his adoptive country before returning to live in his native America. Notes from a Small Island is the irreverent and hilarious account of this meandering journey through his beloved island nation. From Dover to Downing Street, from Giggleswick to Loch Ness by way of Titsey and Nether Wallop, Bryson rejoices in Britain’s inimitable placenames and much else of more substance besides, his very own State of the Nation address, as it were.

A huge number-one bestseller when it was first published, Notes from a Small Island has become that nation's most loved book about Britain.

(Picture: Bill Bryson. Photo credit: Catherine Williams.)

CrowdScience - Can being happy help me fight infection?

Could being happier help us fight infectious disease?

As the world embarks on a mass vaccination programme to protect populations from Covid-19, Crowdscience asks whether our mood has any impact on our immune systems. In other words, could being happier help us fight infectious diseases? Marnie Chesterton explores how our mental wellbeing can impact our physical health and hears that stress and anxiety make it harder for our natural defence systems to kick in – a field known as psychoneuroimmunology. Professor Kavita Vedhara from the University of Nottingham explains flu jabs are less successful in patients with chronic stress.

So scientists are coming up with non-pharmacological ways to improve vaccine efficiency. We investigate the idea that watching a short feel-good video before receiving the inoculation could lead to increased production of antibodies to a virus. And talk to Professor Richard Davidson who says mindfulness reduces stress and makes vaccines more effective.

[Image: Happy couple wearing masks. Credit: Getty Images]

Science In Action - Mixing Covid vaccines

A new trial is about to start in the UK, seeing if different vaccines can be mixed and matched in a two-dose schedule, and whether the timing matters. Governments want to know the answer as vaccines are in short supply. Oxford University’s Matthew Snape takes Roland Pease through the thinking.

Despite the numbers of vaccines being approved for use we still need treatments for Covid-19. A team at the University of North Carolina is upgrading the kind of manufactured antibodies that have been used to treat patients during the pandemic, monoclonal antibodies. Lisa Gralinski explains how they are designing souped-up antibodies that’ll neutralise not just SARS-CoV-2, but a whole range of coronaviruses.

Before global warming, the big ecological worry that exercised environmentalists was acid rain. We’d routinely see pictures of forests across the world dying because of the acid soaking they’d had poisoning the soil. In a way, this has been one of environmental activism’s success stories. The culprit was sulphur in coal and in forecourt fuels – which could be removed, with immediate effect on air quality. But biogeochemist Tobias Goldhammer of the Leibniz Institute in Berlin and colleagues have found that sulphur, from other sources, is still polluting water courses.

There’s been debate over when and where dogs became man’s best friend. Geoff Marsh reports on new research from archaeology and genetics that puts the time at around 20,000 years ago and the place as Siberia.

(Image: Getty Images)

Presenter: Roland Pease Producer: Deborah Cohen

CrowdScience - Will giving up alcohol improve my sperm count?

When planning to have a baby, women are expected to give up everything from smoking to alcohol, even soft cheese. But the other half of fertility comes from the sperm, usually provided by a man. So should men also give up their vices to improve the quality of their sperm, and their chances of conception? That’s what Listener Stuart in Australia wants to know. He emailed CrowdScience after he and his wife had been trying to have a second child for two years. He gave up alcohol, and coffee, but wants to know if there is any hard science to back up the idea that this would improve his fertility.

To find out, presenter Anand Jagatia speaks with Professor Allan Pacey, a scientist who specialises in the study of male fertility and sperm. He discovers that male subfertility accounts for 50% the problems with getting pregnant. And we’re far from alone. Sperm is a remarkably diverse, but also fragile cell. Across the animal kingdom, different species have problems with male fertility, but have adapted novel ways to improve their chances of reaching the egg.

Men often struggle to speak about their fertility, and reporter Chhavi Sachdev tells Anand the impact this has on couples in India who struggle to conceive, or don’t want to. She speaks with fertility specialist Professor Nirmal Kumar Lohiya about how this reticence to speak about fertility is changing.

Viruses from Mumps to HIV have long been known to target the delicate sperm production cells in the testicles. Dr Krutika Kuppalli tells Anand why, and what we know about the possible impact of SARS CoV-2 on male fertility.

Professor Allan Pacey gives Anand and Stuart some advice for what to do while trying to conceive - don’t wear tight underwear - and get used to talking about your swimmers or even getting them checked out.

Contributors: Professor Allan Pacey - Andrologist at the University of Sheffield in the UK. Dr Nicolla Hemmings, expert on bird sperm, Royal Society Dorothy Hodgkin Research Fellow at the University of Sheffield, UK. Professor Nirmal Kumar Lohiya, Fertility specialist and co-developer of RISUG male contraceptive, University of Rajasthan, India Dr Krutika Kuppalli, Assistant Professor at the Medical University of South Carolina, USA

Chhavi Sachdev, Reporter and presenter for CrowdScience

Presented by Anand Jagatia, Produced by Rory Galloway

(Image: Sperm cells Credit: Getty images)

Science In Action - New Covid vaccine

Researchers at Imperial College have been working on a strategy that can make RNA vaccines stretch further. Anna Blakely explains how the new approach works and why RNA vaccines are adaptable to a changing disease. In January 2019 a dam collapsed in Brazil, spilling 10 million cubic metres of red sludge down nearby rivers, claiming the lives of at least 259 people. An engineering report into the collapse looked at data from safety sensors around the site, and said they’d not revealed any weakening of the dam prior to the failure. But a new study using data from Earth observing satellites has found signs of subtle movement starting weeks earlier. Stephen Grebby of Nottingham University and Roland Pease discuss this finding. An international collaboration led by Kew Gardens has just set out a list of ten golden rules for maintaining and restoring forests. The main author, Kate Hardwick talks about why the rules are necessary and why it isn’t as simple as planting any old trees. There’s been a lot of debate about whether being bilingual is good for the brain. Does knowing more than one language take up precious capacity that could be used for better things? Or does it sharpen it, all the better to take on more challenges? Dean d’Souza of Anglia Ruskin University has been addressing this question by comparing the behaviour of infants brought up in monolingual and multilingual homes.

(Image: Getty Images)

Presenter: Roland Pease Producer: Deborah Cohen

Unexpected Elements - Saving the Northern White Rhino

Northern white rhinos are extinct in the wild and there are just two females in captivity in Kenya. Conservationists are working on an artificial breeding programme, using eggs from the females and sperm from a deceased male. Now five embryos have been created. Thomas Hildebrandt of the Leibniz Institute for Zoo and Wildlife Research in Berlin explained the research.

President Biden’s first executive order was what’s being called the hundred-day mask mandate. The day before the inauguration a massive analysis of mask-wearing and COVID rates demonstrated a clear, if small, benefit. Epidemiologist Ben Rader told Roland Pease that it got over 300,000 opinions by using the online questionnaire, SurveyMonkey.

After the alarming series of record-breaking heatwaves last year, global warming is causing specific problems in the innumerable lakes around the world. Lakes are ecologically particularly vulnerable to extremes. The European Space Agency’s Yestyn Woolway has been analysing past trends, and modelling the future.

2020 delivered a record year in hurricanes, which caused around $60 billion dollars in damage to the US alone, according to one estimate. A new technology called Airborne Phased-Array Radar promises to improve the measurements that are currently made by planes that fly right into the eye of the hurricanes, and make the missions safe. It’s being developed at the National Centre for Atmospheric Research and Roland discussed the new technology with the Director of NCAR, Vanda Grubišić.

And Covid-19 has prompted a cleaning frenzy. CrowdScience listener William works as a personal trainer in a gym, and while cleaning’s always been part of his job, it’s now taken over much of his working day. He’s constantly wiping down equipment and doing regular deep cleans, and he reckons he can sanitize his hands 40 times in one shift.

This kind of routine might strike a chord with many of us, and it’s certainly vital to take hygiene seriously during times of pandemic.

But could there be any downsides to all this extra cleaning? There’s a whole world of microbes out there: some, like SARS-CoV-2, make us sick, but others are essential for our health. A rich microbiome is linked to a healthy immune system, while ‘good’ microbes help keep ‘bad’ ones at bay. And what about the chemicals in cleaning products – do they have any unintended consequences for our health?

CrowdScience turns to the experts to ask whether our supercharged hygiene routines could damage our immune systems, or promote the spread of superbugs. And we hear why, as long as we have a good diet, plenty of fresh air, and ideally a furry pet, we don’t need to worry too much about being too clean.

(Image; Najin and Fatu, the only two remaining female northern white rhinos graze in their paddock. Credit: Tony Karumba/AFP via Getty Images)

CrowdScience - Are there downsides to deep cleaning?

Covid-19 has prompted a cleaning frenzy. CrowdScience listener William works as a personal trainer in a gym, and while cleaning’s always been part of his job, it’s now taken over much of his working day. He’s constantly wiping down equipment and doing regular deep cleans, and he reckons he can sanitize his hands 40 times in one shift.

This kind of routine might strike a chord with many of us, and it’s certainly vital to take hygiene seriously during times of pandemic.

But could there be any downsides to all this extra cleaning? There’s a whole world of microbes out there: some, like SARS-CoV-2, make us sick, but others are essential for our health. A rich microbiome is linked to a healthy immune system, while ‘good’ microbes help keep ‘bad’ ones at bay. And what about the chemicals in cleaning products – do they have any unintended consequences for our health?

CrowdScience turns to the experts to ask whether our supercharged hygiene routines could damage our immune systems, or promote the spread of superbugs. And we hear why, as long as we have a good diet, plenty of fresh air, and ideally a furry pet, we don’t need to worry too much about being too clean.

Presented by Marnie Chesterton Produced by Cathy Edwards for the BBC World Service

(Photo credit: Getty Images)

Science In Action - Saving the Northern White Rhino

Northern white rhinos are extinct in the wild and there are just two females in captivity in Kenya. Conservationists are working on an artificial breeding programme, using eggs from the females and sperm from a deceased male. Now five embryos have been created. Thomas Hildebrandt of the Leibniz Institute for Zoo and Wildlife Research in Berlin explained the research.

President Biden’s first executive order was what’s being called the hundred-day mask mandate. The day before the inauguration a massive analysis of mask-wearing and COVID rates demonstrated a clear, if small, benefit. Epidemiologist Ben Rader told Roland Pease that it got over 300,000 opinions by using the online questionnaire, SurveyMonkey.

After the alarming series of record-breaking heatwaves last year, global warming is causing specific problems in the innumerable lakes around the world. Lakes are ecologically particularly vulnerable to extremes. The European Space Agency’s Yestyn Woolway has been analysing past trends, and modelling the future.

2020 delivered a record year in hurricanes, which caused around $60 billion dollars in damage to the US alone, according to one estimate. A new technology called Airborne Phased-Array Radar promises to improve the measurements that are currently made by planes that fly right into the eye of the hurricanes, and make the missions safe. It’s being developed at the National Centre for Atmospheric Research and Roland discussed the new technology with the Director of NCAR, Vanda Grubišić.

(Image; Najin and Fatu, the only two remaining female northern white rhinos graze in their paddock. Credit: Tony Karumba/AFP via Getty Images)

Presenter: Roland Pease Producer: Deborah Cohen