Science In Action - Rolling out the vaccines faster

Two weeks ago several G7 leaders called for an international treaty on Pandemic Preparedness for the future. This week 175 prominent leaders called for lifting the IP on vaccine design. And former UK PM Gordon Brown called on the G7 to finance vaccines for the world in the next two months. But are there technical difficulties that limit the pace of manufacture?

Anthony McDonnell is an economist at think tank Centre for Global Development who has been looking at the problem since last year. He suggests, amongst other things, one limit is the human expertise in manufacturing these brand-new technologies, with another being a level of vaccine nationalism that is seeing a lack of exports of components involved in manufacture.

Professor Trudie Lang heads the University of Oxford’s Global Health Network, and looks at health research across the world. She says in most countries there is no lack of public health or infrastructure potential for rolling out the vaccines, if only the supply existed.

The volcano that erupted explosively on St Vincent last week has led to many thousands of people being evacuated. Dr Joan Latchman of the University of West Indies Seismic Research Centre - who has monitored Caribbean volcanos for several decades - describes from Trinidad how the layers of ash mean recovery will take a long time, even if the explosions and pyroclastic dangers subside reasonably soon. Back in The UK, Prof Jenni Barclay and colleagues are examining rocks from the early part of the eruption, before the explosive phase began, to see if there are clues in the microstructure that could provide clues to the future.

And how do our brains so quickly tell a scream of delight from a scream of horror? Or of pain? Prof Sascha Frühholz of the University of Geneva has written in the journal PLOS Biology this week about work looking at how we identify the nature of different human screams. One finding is that we perceive joy quicker than fear..

(Image: Getty Images)

Presenter: Roland Pease Producer: Alex Mansfield

Focus on Africa - Burkina Faso: Compaore to be tried over Sankara assassination

Burkina Faso’s former president Blaise Compaore faces a military trial, accused of involvement in the killing of his predecessor Thomas Sankara.

Plus, more than 40 people have died after their boat got into trouble between Yemen and Djibouti.

And we meet the children’s author from Sierra Leone who wants to decolonise the alphabet.

CrowdScience - Why do we gossip?

Gossip often has negative connotations, but does it get a bad rap? Might it serve a useful function and should we think of gossiping as an advanced social skill rather than a personality defect? CrowdScience listener Jayogi thinks it might be useful, and has asked CrowdScience to dig into the reasons why we find it so hard to resist salacious stories.

Presenter Datshiane Navanayagam meets a scientist who views gossip as a key evolutionary adaption - as humans started to live in bigger cooperative groups, gossiping was a way of bonding and establishing acceptable group behaviour as well as cementing reputations of trustworthiness.

Datshiane heads to the local park to catch some real gossiping in action and finds out that whilst people like to gossip they don’t consider themselves gossipers.

Datshi asks a team of scientists what information we are most keen to share and glean in these interactions and if there is such a thing as ‘good’ and ‘bad’ gossip. She hears that in some group settings – like in the workplace - gossip can enhance cooperation and limit free-riders, but that it can also have a more self-serving dark side.

Datshiane finds out if our stone-age gossipy minds are fit to operate in the world of mass communication and social media – is our fixation on celebrities related to our being hard wired to gossip?

Presenter: Datshiane Navanayagam Producer: Melanie Brown

[Image: Gossiping people. Credit: Getty Images]

Science In Action - On the trail of rare blood clots

On Wednesday the EU’s EMA and UK’s JCVI announced a suspected correlation between vaccination and an extremely rare type of blood clot. Prof Sabine Eichinger is a co-author of a new paper suggesting a link with vaccination or the immune response to Covid vaccination and suggests the name VIPIT for the condition. One of her patients died at the end of February having presented with a rare combination of symptoms – blood clots and a low blood platelet count. Sabine tells Roland the dots they have managed to join in the story so far.

Scientists at Fermilab in the USA posted four papers and announced an exciting development in particle physics that might lift the curtain on science beyond the Standard Model. Their measurement of something known as g-2 (“gee minus two”, just fyi), by measuring with phenomenal accuracy the magnetic properties of muons flying round in circles confirms a 20-year old attempt at a similar value by colleagues at Brookhaven. At the time, it was breathtaking but suspicious. Muons, rather like heavy electrons, don’t quite behave as the Standard Model might have us believe, hinting at fields and possibly particles or forces hitherto unknown. Dr. Harry Cliffe – a member of the LHCb team who found something similarly weird two weeks ago - describes the finding and the level of excitement amongst theorists worldwide.

Superfans around the world have learned to speak fluent Klingon, a fictional language originating from Star Trek. In a quest to understand the science behind these languages often dismissed as gobbledygook, Gaia Vince has been speaking to some of the linguists responsible for creating these languages. It’s time for her to relax the tongue, loosen those jaw muscles and wrap her head around the scientific building blocks embedded in language and what languages like Klingon tell us about prehistoric forms of communication.

Meanwhile, primatologist Edward Wright of the Max Plank Institute has been hanging out with mountain gorillas in Rwanda and recording the sound of their “chest clapping”. As he describes in the journal Scientific Reports his work confirms what scientists have long suspected - that the famous gesture - often portrayed in films - is a measure of size and strength - allowing communication in the dense, tropical forests in which the animals live.

Image: Platelets, computer illustration. Credit: Sebastian Kaulitzki /Science Photo Library via Getty Images

Presenter: Roland Pease Producer: Alex Mansfield

Focus on Africa - Tanzania’s new president charts new Covid-19 course for the country

Tanzania’s new President Samia Suluhu Hassan has outlined a shift in government policy in the areas of media freedom, Covid-19 response and foreign policy.

Sudan has declared a state of emergency in west Darfur following deadly tribal clashes.

And why Zimbabwe's once famed education system has become a pale shadow of its former self.

World Book Club - Robert Seethaler: A Whole Life

Spanning much of the twentieth century and told with an elegant simplicity which belies the harshness of the tale it tells, Robert Seethaler's A Whole Life is the story of one man's relationship with an ancient landscape.

Andreas Egger knows every nook and cranny of the Alpine mountain valley that is his home and from which vantage point he witnesses the arrival of the modern world, in all its many and daunting forms.

A stark yet tender book about love, loss and endurance, and about finding dignity and beauty in solitude A Whole Life has already touched many thousands of readers with its message of solace and truth.

(Picture: Robert Seethaler. Photo credit: UrbanZintel.)

World Book Club - Robert Seethaler: A Whole Life

Spanning much of the twentieth century and told with an elegant simplicity which belies the harshness of the tale it tells, Robert Seethaler's A Whole Life is the story of one man's relationship with an ancient landscape.

Andreas Egger knows every nook and cranny of the Alpine mountain valley that is his home and from which vantage point he witnesses the arrival of the modern world, in all its many and daunting forms.

A stark yet tender book about love, loss and endurance, and about finding dignity and beauty in solitude A Whole Life has already touched many thousands of readers with its message of solace and truth.

(Picture: Robert Seethaler. Photo credit: UrbanZintel.)

CrowdScience - If a tree falls in a forest does it make a sound?

If a tree falls in a forest, and no-one is there to hear it, does it make a sound? This is an age-old debate that listener Richard and his family have been arguing about for years. Can CrowdScience settle it once and for all?

Caroline Steel speaks to experts in hearing, biology, philosophy, physics and sound design, which takes her to some unexpected places.

Professor Stefan Bleek is an expert in psychoacoustics who says that sounds only exist in our heads. Dr Eleanor Knox and Dr Bryan Roberts are philosophers that make her question if anything exists outside our own perception. Professor Lilach Hadany wonders if it’s limited to humans and animals - could other plants hear the falling tree too? And Mat Eric Hart is a sound designer who says that sound is subjective – it’s always tangled up with our own interpretations.

Things get truly weird as we delve into the strange implications of quantum physics. If there is such a thing as reality, doesn’t it change when we’re there to observe it? Does the tree even fall if we aren’t there?

Presenter: Caroline Steel Producer: Anand Jagatia

(Image: Fallen Tree. Credit: Getty Images)

Science In Action - Post-Covid outcomes after release from hospital

After last year’s first wave of covid-19 in the UK, individuals who had been discharged after hospitalisation suffered higher rates of coronary and respiratory disorders, and even diabetes subsequently over 140 days. As Dr Ami Banerjee of University College London explains, out of 48,000 cases, patients who had had acute covid-19 were four times more likely to be readmitted and 8 times more likely to die. Ami’s team suggests in their paper published in the British Medical Journal that diagnosis, treatment and prevention of post-covid syndrome needs an integrated approach.

In France, researcher Xavier Montagutelli describes how his team has observed that unlike the original virus, some of the newer Variants of Concern can infect mice in laboratories. They do not show serious illness, but nevertheless host the virus in their lungs. Whilst infection is unlikely in natural environments and not yet observed in the wild, it does show how the viral variants can extend the host range, perhaps leading to more opportunities for mutation. But this finding, posted as a pre-print, also perhaps represents an avenue for deeper gene-specific research that has not so far been possible.

Over in Colombia, Monica Carvalho of the Smithsonian Tropical Research Institute describes her team’s findings regarding the origins of the diversity and habitat of rainforests in south America. Looking at leaf fossils and pollen grains from 60 million years ago, they have found significant differences between the forests of the dinosaurs, and the ones we see today. As they write in the journal Science, it all changed when the Chixulub meteor hit the Gulf of Mexico and the global lights went out. The rainforests that grew back were simply not the same.

But much further back in time, some billion years ago, the forests of the world that were changing the chemistry and making seas inhabitable allowing complex multicellular life, consisted of pencil-lead sized algae quietly photosynthesizing in the shallows of an ocean in what is today remote Canada. Katie Maloney of University of Toronto Mississauga spotted fossils of just these when out on a field trip in Yukon territory. Publishing in Geology Magazine this week, her eagle-eyed finds shed light on this crucial epoch in life history of which there are scant fossilized remains.

Image: Rainforest canopy Credit: Universal Images Group via Getty Images

Presenter: Roland Pease Producer: Alex Mansfield