Author: BBC World Service

A new trial is about to start in the UK, seeing if different vaccines can be mixed and matched in a two-dose schedule, and whether the timing matters. Governments want to know the answer as vaccines are in short supply. Oxford University’s Matthew Snape takes Roland Pease through the thinking.

Despite the numbers of vaccines being approved for use we still need treatments for Covid-19. A team at the University of North Carolina is upgrading the kind of manufactured antibodies that have been used to treat patients during the pandemic, monoclonal antibodies. Lisa Gralinski explains how they are designing souped-up antibodies that’ll neutralise not just SARS-CoV-2, but a whole range of coronaviruses.

Before global warming, the big ecological worry that exercised environmentalists was acid rain. We’d routinely see pictures of forests across the world dying because of the acid soaking they’d had poisoning the soil. In a way, this has been one of environmental activism’s success stories. The culprit was sulphur in coal and in forecourt fuels – which could be removed, with immediate effect on air quality. But biogeochemist Tobias Goldhammer of the Leibniz Institute in Berlin and colleagues have found that sulphur, from other sources, is still polluting water courses.

There’s been debate over when and where dogs became man’s best friend. Geoff Marsh reports on new research from archaeology and genetics that puts the time at around 20,000 years ago and the place as Siberia.

(Image: Getty Images)

Presenter: Roland Pease Producer: Deborah Cohen

When planning to have a baby, women are expected to give up everything from smoking to alcohol, even soft cheese. But the other half of fertility comes from the sperm, usually provided by a man. So should men also give up their vices to improve the quality of their sperm, and their chances of conception? That’s what Listener Stuart in Australia wants to know. He emailed CrowdScience after he and his wife had been trying to have a second child for two years. He gave up alcohol, and coffee, but wants to know if there is any hard science to back up the idea that this would improve his fertility.

To find out, presenter Anand Jagatia speaks with Professor Allan Pacey, a scientist who specialises in the study of male fertility and sperm. He discovers that male subfertility accounts for 50% the problems with getting pregnant. And we’re far from alone. Sperm is a remarkably diverse, but also fragile cell. Across the animal kingdom, different species have problems with male fertility, but have adapted novel ways to improve their chances of reaching the egg.

Men often struggle to speak about their fertility, and reporter Chhavi Sachdev tells Anand the impact this has on couples in India who struggle to conceive, or don’t want to. She speaks with fertility specialist Professor Nirmal Kumar Lohiya about how this reticence to speak about fertility is changing.

Viruses from Mumps to HIV have long been known to target the delicate sperm production cells in the testicles. Dr Krutika Kuppalli tells Anand why, and what we know about the possible impact of SARS CoV-2 on male fertility.

Professor Allan Pacey gives Anand and Stuart some advice for what to do while trying to conceive - don’t wear tight underwear - and get used to talking about your swimmers or even getting them checked out.

Contributors: Professor Allan Pacey - Andrologist at the University of Sheffield in the UK. Dr Nicolla Hemmings, expert on bird sperm, Royal Society Dorothy Hodgkin Research Fellow at the University of Sheffield, UK. Professor Nirmal Kumar Lohiya, Fertility specialist and co-developer of RISUG male contraceptive, University of Rajasthan, India Dr Krutika Kuppalli, Assistant Professor at the Medical University of South Carolina, USA

Chhavi Sachdev, Reporter and presenter for CrowdScience

Presented by Anand Jagatia, Produced by Rory Galloway

(Image: Sperm cells Credit: Getty images)

Researchers at Imperial College have been working on a strategy that can make RNA vaccines stretch further. Anna Blakely explains how the new approach works and why RNA vaccines are adaptable to a changing disease. In January 2019 a dam collapsed in Brazil, spilling 10 million cubic metres of red sludge down nearby rivers, claiming the lives of at least 259 people. An engineering report into the collapse looked at data from safety sensors around the site, and said they’d not revealed any weakening of the dam prior to the failure. But a new study using data from Earth observing satellites has found signs of subtle movement starting weeks earlier. Stephen Grebby of Nottingham University and Roland Pease discuss this finding. An international collaboration led by Kew Gardens has just set out a list of ten golden rules for maintaining and restoring forests. The main author, Kate Hardwick talks about why the rules are necessary and why it isn’t as simple as planting any old trees. There’s been a lot of debate about whether being bilingual is good for the brain. Does knowing more than one language take up precious capacity that could be used for better things? Or does it sharpen it, all the better to take on more challenges? Dean d’Souza of Anglia Ruskin University has been addressing this question by comparing the behaviour of infants brought up in monolingual and multilingual homes.

(Image: Getty Images)

Presenter: Roland Pease Producer: Deborah Cohen

Northern white rhinos are extinct in the wild and there are just two females in captivity in Kenya. Conservationists are working on an artificial breeding programme, using eggs from the females and sperm from a deceased male. Now five embryos have been created. Thomas Hildebrandt of the Leibniz Institute for Zoo and Wildlife Research in Berlin explained the research.

President Biden’s first executive order was what’s being called the hundred-day mask mandate. The day before the inauguration a massive analysis of mask-wearing and COVID rates demonstrated a clear, if small, benefit. Epidemiologist Ben Rader told Roland Pease that it got over 300,000 opinions by using the online questionnaire, SurveyMonkey.

After the alarming series of record-breaking heatwaves last year, global warming is causing specific problems in the innumerable lakes around the world. Lakes are ecologically particularly vulnerable to extremes. The European Space Agency’s Yestyn Woolway has been analysing past trends, and modelling the future.

2020 delivered a record year in hurricanes, which caused around $60 billion dollars in damage to the US alone, according to one estimate. A new technology called Airborne Phased-Array Radar promises to improve the measurements that are currently made by planes that fly right into the eye of the hurricanes, and make the missions safe. It’s being developed at the National Centre for Atmospheric Research and Roland discussed the new technology with the Director of NCAR, Vanda Grubišić.

And Covid-19 has prompted a cleaning frenzy. CrowdScience listener William works as a personal trainer in a gym, and while cleaning’s always been part of his job, it’s now taken over much of his working day. He’s constantly wiping down equipment and doing regular deep cleans, and he reckons he can sanitize his hands 40 times in one shift.

This kind of routine might strike a chord with many of us, and it’s certainly vital to take hygiene seriously during times of pandemic.

But could there be any downsides to all this extra cleaning? There’s a whole world of microbes out there: some, like SARS-CoV-2, make us sick, but others are essential for our health. A rich microbiome is linked to a healthy immune system, while ‘good’ microbes help keep ‘bad’ ones at bay. And what about the chemicals in cleaning products – do they have any unintended consequences for our health?

CrowdScience turns to the experts to ask whether our supercharged hygiene routines could damage our immune systems, or promote the spread of superbugs. And we hear why, as long as we have a good diet, plenty of fresh air, and ideally a furry pet, we don’t need to worry too much about being too clean.

(Image; Najin and Fatu, the only two remaining female northern white rhinos graze in their paddock. Credit: Tony Karumba/AFP via Getty Images)

Covid-19 has prompted a cleaning frenzy. CrowdScience listener William works as a personal trainer in a gym, and while cleaning’s always been part of his job, it’s now taken over much of his working day. He’s constantly wiping down equipment and doing regular deep cleans, and he reckons he can sanitize his hands 40 times in one shift.

This kind of routine might strike a chord with many of us, and it’s certainly vital to take hygiene seriously during times of pandemic.

But could there be any downsides to all this extra cleaning? There’s a whole world of microbes out there: some, like SARS-CoV-2, make us sick, but others are essential for our health. A rich microbiome is linked to a healthy immune system, while ‘good’ microbes help keep ‘bad’ ones at bay. And what about the chemicals in cleaning products – do they have any unintended consequences for our health?

CrowdScience turns to the experts to ask whether our supercharged hygiene routines could damage our immune systems, or promote the spread of superbugs. And we hear why, as long as we have a good diet, plenty of fresh air, and ideally a furry pet, we don’t need to worry too much about being too clean.

Presented by Marnie Chesterton Produced by Cathy Edwards for the BBC World Service

(Photo credit: Getty Images)

Northern white rhinos are extinct in the wild and there are just two females in captivity in Kenya. Conservationists are working on an artificial breeding programme, using eggs from the females and sperm from a deceased male. Now five embryos have been created. Thomas Hildebrandt of the Leibniz Institute for Zoo and Wildlife Research in Berlin explained the research.

President Biden’s first executive order was what’s being called the hundred-day mask mandate. The day before the inauguration a massive analysis of mask-wearing and COVID rates demonstrated a clear, if small, benefit. Epidemiologist Ben Rader told Roland Pease that it got over 300,000 opinions by using the online questionnaire, SurveyMonkey.

After the alarming series of record-breaking heatwaves last year, global warming is causing specific problems in the innumerable lakes around the world. Lakes are ecologically particularly vulnerable to extremes. The European Space Agency’s Yestyn Woolway has been analysing past trends, and modelling the future.

2020 delivered a record year in hurricanes, which caused around $60 billion dollars in damage to the US alone, according to one estimate. A new technology called Airborne Phased-Array Radar promises to improve the measurements that are currently made by planes that fly right into the eye of the hurricanes, and make the missions safe. It’s being developed at the National Centre for Atmospheric Research and Roland discussed the new technology with the Director of NCAR, Vanda Grubišić.

(Image; Najin and Fatu, the only two remaining female northern white rhinos graze in their paddock. Credit: Tony Karumba/AFP via Getty Images)

Presenter: Roland Pease Producer: Deborah Cohen

After collecting data for more than twelve years the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) announced it may have detected new kinds of gravitational waves caused by colliding supermassive black holes. Professor Chiara Mingarelli of the University of Connecticut tells Roland Pease why this is such an exciting discovery.

Supermassive black holes are at the heart of galaxies and they are the engines of quasars, the brightest light sources in the heavens that can be seen across the expanse of the Universe. A team including Professor Xiaohui Fan of the University of Arizona has identified the oldest quasar in the universe.

The SARS-CoV-2 virus looks much like bat coronaviruses, but the mostly likely route into humans involved some other infected animal. Roland talks to Dr Dalan Bailey of The Pirbright Institute about how he has been looking for possible intermediaries.

A new study that looks into the genetics of twins and their families in Iceland shows that identical twins aren’t really identical. Kari Stefansson of the Icelandic genome company, DeCode, explains that the differences can appear when the twins are at the embryonic stage.

And , When it comes to speed, humans have got nothing on cheetahs - or greyhounds, kangaroos or zebras for that matter. It’s over long distances we really come into our own: when running for hours or even days, our body structure and excellent sweating skills make us able to outpace much faster mammals.

But what are the limits of human endurance? Can we run ever further and faster, and what’s the best diet to fuel such ambitions?

This week’s questions come from two CrowdScience listeners in Japan who already know a fair bit about stamina, having run several marathons and long-distance triathlons between them. We head to Greece, legendary birthplace of the marathon, to witness an even more arduous challenge: hundreds of athletes following in the footsteps of the ancient Greek messenger Pheidippides, to run an astonishing 246km across the country. The ever-so-slightly less fit CrowdScience team do our best to keep up, and try to discover the secrets of these runners’ incredible endurance.

(Image: Representative illustration of the Earth embedded in space-time which is deformed by the background gravitational waves and its effects on radio signals coming from observed pulsars. Credit: Tonia Klein / NANOGrav)

When it comes to speed, humans have got nothing on cheetahs - or greyhounds, kangaroos or zebras for that matter. It’s over long distances we really come into our own: when running for hours or even days, our body structure and excellent sweating skills make us able to outpace much faster mammals.

But what are the limits of human endurance? Can we run ever further and faster, and what’s the best diet to fuel such ambitions?

This week’s questions come from two CrowdScience listeners in Japan who already know a fair bit about stamina, having run several marathons and long-distance triathlons between them. We head to Greece, legendary birthplace of the marathon, to witness an even more arduous challenge: hundreds of athletes following in the footsteps of the ancient Greek messenger Pheidippides, to run an astonishing 246km across the country. The ever-so-slightly less fit CrowdScience team do our best to keep up, and try to discover the secrets of these runners’ incredible endurance.

Presenter: Marnie Chesterton Producer: Cathy Edwards

(Photo: a runner in the Spartathlon ultramarathon, with kind permission from the International Spartathlon Association)

After collecting data for more than twelve years the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) announced it may have detected new kinds of gravitational waves caused by colliding supermassive black holes. Professor Chiara Mingarelli of the University of Connecticut tells Roland Pease why this is such an exciting discovery.

Supermassive black holes are at the heart of galaxies and they are the engines of quasars, the brightest light sources in the heavens that can be seen across the expanse of the Universe. A team including Professor Xiaohui Fan of the University of Arizona has identified the oldest quasar in the universe. The SARS-CoV-2 virus looks much like bat coronaviruses, but the most likely route into humans involved some other infected animal. Roland talks to Dr Dalan Bailey of The Pirbright Institute about how he has been looking for possible intermediaries.

A new study that looks into the genetics of twins and their families in Iceland shows that identical twins aren’t really identical. Kari Stefansson of the Icelandic genome company, DeCode, explains that the differences can appear when the twins are at the embryonic stage.

(Image: Representative illustration of the Earth embedded in space-time which is deformed by the background gravitational waves and its effects on radio signals coming from observed pulsars. Credit: Tonia Klein / NANOGrav)

Presenter: Roland Pease Producer: Deborah Cohen

Mutant strains of SARS-Cov2 have been identified not only in the UK, where it was first identified, but also in at least 30 other countries. And to complicate matters, another alarming variant, with some similar mutations, has arisen in South Africa. Roland Pease talks to Ravi Gupta, a virologist at Cambridge University and Tulio de Oliveira of the University of KwaZulu Natal about these new strains. There’s only so much that can be learned about the virus by looking at the patients it infects. Thanks to techniques developed to study HIV, Ebola, flu and other viruses in the past, researchers have methods for growing key parts of viral structures in the lab and watching closely how they behave in cell cultures. Jeremy Luban of the University of Massachusetts and Alli Greaney at the Fred Hutchinson Cancer Research Center talk to Roland about how they are studying the biology of the mutations to discover how the new strains might respond to vaccines.

And, one of the more surprising consequences of the pandemic has been the trend for people wanting to move out of cities and back to the countryside. Not everyone has that privilege of course, but undoubtedly for some living in urban areas during lockdown, the lack of access to green spaces took its toll on their mental health and physical well-being. Now, with renewed hope of a global vaccine roll-out, ensuring more people have better access to nature is more important than ever, especially in cities of glass, steel and concrete.

Italian CrowdScience listener Enrica loves nothing better than walking along the verdant riverbank near her home after a hard week at work. But is this activity doing more than making her feel good? Is it having an actual effect on her health? Presenter Anand Jagatia meets Enrica and visits a radical scheme in the city of Milan, where officials have been working hard to increase urban green features and have committed to planting 3 million trees and building twenty new parks by 2030.

One such idea is the innovative Bosco Verticale - or vertical forest, planted up the side of two high rises apartment blocks. Amongst other benefits It’s hoped it could provide cooling microclimates to reduce the dangers

(Image: Swab test. Credit: Getty Images)