Author: BBC World Service

There's been encouraging news about the Oxford Covid-19 vaccine this week from a trial involving about 1,000 people. But how great is the challenge in scaling up from making a few thousand doses of the vaccine to manufacturing two billion by the end of this year? Sandy Douglas of Oxford's Jenner Institute explains how they plan to mass-produce the vaccine safely given the speed and magnitude of the scale up.

A new kind of treatment for Covid-19 may come from an unlikely source: llamas and alpacas, the South American relatives of the camel. Camelids produce unusually small and simple antibodies against viruses, including the coronavirus. This feature may make these molecules an effective Covid-19 therapy. Jane Chambers reports on research in Chile and the UK.

Also in the programme: what has made just a few mosquito species evolve a preference for biting humans, and the theory that 800 million years ago the Moon and the Earth were bombarded by a shower of asteroids which plunged the Earth into a global ice age - an event which changed the course of the evolution of life.

These days we're more acquainted with soap than ever before, as we lather up to help stop the spread of coronavirus. And for CrowdScience listener Sharon, this set off a steady stream of soapy questions: how does soap actually work? How was it discovered in the first place, long before anyone knew anything about germs? Are different things used for washing around the world, and are some soaps better than others?

We set up a CrowdScience home laboratory to explore the soap making process with advice from science-based beauty blogger Dr Michelle Wong, and find out what it is about soap's chemistry that gives it its germ-fighting superpowers. Soap has been around for at least 4000 years; we compare ancient soap making to modern methods, and hear about some of the soap alternatives used around the world, like the soap berries of India.

And as for the question of whether some soaps are better than others? We discover why antibacterial soaps aren't necessarily a good idea, and why putting a toy inside a bar of soap might be more important than tweaking its ingredients.

(Image: A team of experts at the University of Oxford are working to develop a vaccine that could prevent people from getting Covid-19. Credit: Press Association)

These days we’re more acquainted with soap than ever before, as we lather up to help stop the spread of coronavirus. And for CrowdScience listener Sharon, this set off a steady stream of soapy questions: how does soap actually work? How was it discovered in the first place, long before anyone knew anything about germs? Are different things used for washing around the world, and are some soaps better than others? We set up a CrowdScience home laboratory to explore the soap making process with advice from science-based beauty blogger Dr Michelle Wong, and find out what it is about soap’s chemistry that gives it its germ-fighting superpowers. Soap has been around for at least 4000 years; we compare ancient soap making to modern methods, and hear about some of the soap alternatives used around the world, like the soap berries of India.

And as for the question of whether some soaps are better than others? We discover why antibacterial soaps aren’t necessarily a good idea, and why putting a toy inside a bar of soap might be more important than tweaking its ingredients.

Presented by Marnie Chesterton. Produced by Cathy Edwards for the BBC World Service.

Image: Child with thoroughly washed hands. Credit: Getty Images.

There’s been encouraging news about the Oxford Covid-19 vaccine this week from a trial involving about 1,000 people. But how great is the challenge in scaling up from making a few thousand doses of the vaccine to manufacturing two billion by the end of this year? Sandy Douglas of Oxford’s Jenner Institute explains how they plan to mass-produce the vaccine safely given the speed and magnitude of the scale up.

A new kind of treatment for Covid-19 may come from an unlikely source: llamas and alpacas, the South American relatives of the camel. Camelids produce unusually small and simple antibodies against viruses, including the coronavirus. This feature may make these molecules an effective Covid-19 therapy. Jane Chambers reports on research in Chile and the UK.

Also in the programme: Roland talks to Noah Rose and Lindy McBride of Princeton University about what has made just a few mosquito species evolve a preference for biting humans, and the theory that 800 million years ago. He also talks to Professor Kentaro Terada of Osaka University and David Kring of the Lunar and Planetary Institute in the USA about evidence that the Moon and the Earth were bombarded by a shower of asteroids which plunged the Earth into a global ice age – an event which may have changed the course of the evolution of life.

(Image: A team of experts at the University of Oxford are working to develop a vaccine that could prevent people from getting Covid-19 Credit: Press Association)

Presenter: Roland Pease Producer: Andrew Luck-Baker

Science in Action looks at some of the latest research on how response of our immune system to infection by the coronavirus. Researchers at Kings College London find that protective antibodies appear to fade away after about three months following infection whereas a team at the Karolinska Institute has discovered that although antibodies may decline, other important players called T cells in our defences do not. Dr’s Katie Doores and Marcus Buggert talk about the implications of these discoveries for the quest for a vaccine against the coronavirus.

Roland Pease also talks to Dr Barney Graham of the National Institute of Allergy and Infectious Diseases in the United States about the results from the Phase 1 trial of novel type of vaccine against the virus. NIAID have partnered with biotech company Moderna to produce the first mRNA vaccine in the Institute’s pandemic preparedness program.

Biologist Dr Sonja Wild tells Roland about the remarkable fishing strategy devised by dolphins in Shark Bay, Australia. They chase fish into the empty shell of giant sea snails, then take the shells to the surface and tip the fish into their mouths. Dr Wild’s 7 years of research has revealed how the dolphins have learned to do this.

Think of the oceans and an empty and peaceful expanse relatively untouched by humankind might come to mind. But is this peace an illusion? CrowdScience listener Dani wants to know if the noise of shipping and other human activity on the oceans is impacting on sea life.

To find out, Marnie Chesterton takes a deep dive to learn how marine animals have evolved to use sound; from navigating their environments to finding a mate or hiding from prey. She then speaks to a scientist who is using acoustic observatories to track the many ways human activity - like sonar and shipping – can interfere.

Marnie virtually visits a German lab which tests the ears of beached whales, dolphins and seals from around the world to try and ascertain whether they suffered hearing damage, and what might have caused it. What other smaller creatures are negatively impacted by underwater noise? Marnie learns that acoustic trauma is more widespread than first thought.

As human life continues to expand along ocean waters, what is being done to reduce the impact of sound? Marnie meets some of the designers at the forefront of naval architecture to see how ship design, from propellers to air bubbles and even wind powered vessels can contribute to reducing the racket in the oceans.

Main image: Abs COVID-19 antibody - Viral Infection concept. Credit: Getty Images

Think of the oceans and an empty and peaceful expanse relatively untouched by humankind might come to mind. But is this peace an illusion? CrowdScience listener Dani wants to know if the noise of shipping and other human activity on the oceans is impacting on sea life.

To find out, Marnie Chesterton takes a deep dive to learn how marine animals have evolved to use sound; from navigating their environments to finding a mate or hiding from prey. She then speaks to a scientist who is using acoustic observatories to track the many ways human activity - like sonar and shipping - can interfere.

Marnie virtually visits a German lab which tests the ears of beached whales, dolphins and seals from around the world to try and ascertain whether they suffered hearing damage, and what might have caused it. What other smaller creatures are negatively impacted by underwater noise? Marnie learns that acoustic trauma is more widespread than first thought.

As human life continues to expand along ocean waters, what is being done to reduce the impact of sound? Marnie meets some of the designers at the forefront of naval architecture to see how ship design, from propellers to air bubbles and even wind powered vessels can contribute to reducing the racket in the oceans.

Presented by Marnie Chesterton. Produced by Melanie Brown for the BBC World Service.

Main Image: The front of a humpback whale underneath the sea in Shetland Islands, Scotland, December 2016. Credit: Richard Shucksmith / Barcroft Im / Barcroft Media via Getty Images

Science in Action looks at some of the latest research on the response of our immune system to infection by the coronavirus. Researchers at Kings College London find that protective antibodies appear to fade away after about three months following infection whereas a team at the Karolinska Institute has discovered that although antibodies may decline, other important players called T cells in our defences do not. Doctors Katie Doores and Marcus Buggert talk about the implications of these discoveries for the quest for a vaccine against the coronavirus.

Roland Pease also talks to Dr Barney Graham of the National Institute of Allergy and Infectious Diseases in the United States about the results from the Phase 1 trial of a novel type of vaccine against the virus. NIAID have partnered with biotech company Moderna to produce the first mRNA vaccine in the Institute’s pandemic preparedness program.

Biologist Dr Sonja Wild tells Roland about the remarkable fishing strategy devised by dolphins in Shark Bay, Australia. They chase fish into the empty shell of giant sea snails, then take the shells to the surface and tip the fish into their mouths. Dr Wild’s 7 years of research has revealed how the dolphins have learned to do this.

(Image: Getty Images)

Presenter: Roland Pease Producer: Andrew Luck-Baker

Correction: The audio of this edition has been edited since its initial broadcast. This was to correct an error in Barney Graham’s interview. The phase 3 of the Moderna mRNA vaccine trial is scheduled to begin on 27 July, not 27 January as originally broadcast.

African scientists have developed a reliable, quick and cheap testing method which could be used by worldwide as the basis for mass testing programmes.

The method, which produces highly accurate results, is built around mathematical algorithms developed at the African Institute for Mathematical Sciences in Kigali. We speak to Neil Turok who founded the institute, Leon Mutesa Professor of human genetics on the government coronavirus task force, and Wilfred Ndifon, the mathematical biologist who devised the algorithm.

The virus is mutating as it spreads, but what does this mean? There is particular concern over changes to the spike protein, part of the virus needed to enter human cells. Jeremy Luban has been analysing this mechanism. So far he says ongoing genetic changes seem unlikely to impact on the effectiveness of treatments for Covid -19.

And Heatwaves are increasing, particularly in tropical regions, that’s the finding of a new analysis by climate scientist Sarah Perkins – Kirkpatrick.

Worms are not the cutest of creatures. They’re slimy, often associated with death and tend to bring on feelings of disgust in many of us. But listener Dinesh thinks they’re underrated and wants to know whether earthworms could be the key to our planet’s future agricultural success? He’s an organic farmer in India’s Tamil Nadu province who grows these annelids to add to the soil, and he wants Crowdscience to find out exactly what they’re doing.

Anand Jagatia dons his gardening gloves and digs the dirt on these remarkable creatures, discovering how they can help improve soil quality, prevent fields from becoming waterlogged, and improve microbial numbers, all of which has the potential to increase crop yield.

But he also investigates the so-called ‘earthworm dilemma’ and the idea that in some parts of the world, boreal forest worms are releasing carbon back into the atmosphere, which could have dangerous consequences for climate change.

Main image: People stand in white circles drawn on the ground to adhere to social distancing in Kigali, Rwanda, on May 4, 2020, Photo by Simon Wohlfahrt / AFP via Getty Images

Worms are not the cutest of creatures. They’re slimy, often associated with death and tend to bring on feelings of disgust in many of us. But listener Dinesh thinks they’re underrated and wants to know whether earthworms could be the key to our planet’s future agricultural success? He’s an organic farmer in India’s Tamil Nadu province who grows these annelids to add to the soil, and he wants Crowdscience to find out exactly what they’re doing.

Anand Jagatia dons his gardening gloves and digs the dirt on these remarkable creatures, discovering how they can help improve soil quality, prevent fields from becoming waterlogged, and improve microbial numbers, all of which has the potential to increase crop yield.

But he also investigates the so-called ‘earthworm dilemma’ and the idea that in some parts of the world, boreal forest worms are releasing carbon back into the atmosphere, which could have dangerous consequences for climate change.

(Photo:

African scientists have developed a reliable, quick and cheap testing method which could be used by worldwide as the basis for mass testing programmes.

The method, which produces highly accurate results, is built around mathematical algorithms developed at the African Institute for Mathematical Sciences in Kigali. We speak to Neil Turok who founded the institute, Leon Mutesa Professor of human genetics on the government coronavirus task force, and Wilfred Ndifon, the mathematical biologist who devised the algorithm.

The virus is mutating as it spreads, but what does this mean? There is particular concern over changes to the spike protein, part of the virus needed to enter human cells. Jeremy Luban has been analysing this mechanism. So far he says ongoing genetic changes seem unlikely to impact on the effectiveness of treatments for Covid -19.

And Heatwaves are increasing, particularly in tropical regions, that’s the finding of a new analysis by climate scientist Sarah Perkins – Kirkpatrick.

Presenter: Roland Pease Producer: Julian Siddle

Main image: People stand in white circles drawn on the ground to adhere to social distancing in Kigali, Rwanda, on May 4, 2020, Photo by Simon Wohlfahrt / AFP via Getty Images