Start the Week - Altered Minds

Psychedelic drugs are once again being trialled to treat a range of psychological conditions. The writer Mike Pollan tells Kirsty Wark about the science of LSD and magic mushrooms: from the 1940s to the 1960s they promised to shed light not only on the deep mysteries of consciousness, but also to offer relief from addiction and mental illness. Banned since the 1970s, there is now a resurgence of research into these mind-altering substances.

While some psychiatrists were getting their patients to experiment with psychedelics in the 1950s, far more were administering electroconvulsive therapy - both have a controversial history. ECT involves sending an electric current through the brain to trigger an epileptic seizure. It gained a reputation as a barbaric treatment, after the film One Flew Over The Cuckoo's Nest. But the psychiatrist Dr Tammy Burmeister believes that it's time people understood the therapeutic potential from this procedure.

The poet Andrew Motion's latest book Essex Clay is an attempt to return to heartfelt memories of childhood. He looks back at his mother's riding accident, which left her 'floating herself among the nebulae and gas clouds of her vast unconsciousness' and her subsequent slow death. The book revolves around loss and memory and retrieval.

The evolution of the human brain is one of the wonders of nature, but the philosopher of science Peter Godfrey-Smith asks what if intelligent life on Earth evolved not once, but twice? He wonders how the octopus - a solitary creature - became so smart. He traces the story from single-celled organism 3.8 billion years ago to the development of cephalopod consciousness, casting new light on the octopus mind.

Producer: Katy Hickman.

Start the Week - Altered Minds

Psychedelic drugs are once again being trialled to treat a range of psychological conditions. The writer Mike Pollan tells Kirsty Wark about the science of LSD and magic mushrooms: from the 1940s to the 1960s they promised to shed light not only on the deep mysteries of consciousness, but also to offer relief from addiction and mental illness. Banned since the 1970s, there is now a resurgence of research into these mind-altering substances.

While some psychiatrists were getting their patients to experiment with psychedelics in the 1950s, far more were administering electroconvulsive therapy - both have a controversial history. ECT involves sending an electric current through the brain to trigger an epileptic seizure. It gained a reputation as a barbaric treatment, after the film One Flew Over The Cuckoo's Nest. But the psychiatrist Dr Tammy Burmeister believes that it's time people understood the therapeutic potential from this procedure.

The poet Andrew Motion's latest book Essex Clay is an attempt to return to heartfelt memories of childhood. He looks back at his mother's riding accident, which left her 'floating herself among the nebulae and gas clouds of her vast unconsciousness' and her subsequent slow death. The book revolves around loss and memory and retrieval.

The evolution of the human brain is one of the wonders of nature, but the philosopher of science Peter Godfrey-Smith asks what if intelligent life on Earth evolved not once, but twice? He wonders how the octopus - a solitary creature - became so smart. He traces the story from single-celled organism 3.8 billion years ago to the development of cephalopod consciousness, casting new light on the octopus mind.

Producer: Katy Hickman.

The Gist - Comedians Can Be Well-Adjusted, Too

On The Gist, president Trump raised the bar on what’s considered a gaffe, and EPA head Scott Pruitt is taking advantage of that.

Very few comedians have never been to therapy. Jerry Seinfeld is one. Tom Papa is another. Papa tells us about cracking jokes at Minnesota Public Radio’s Live From Here and his new book, Your Dad Stole My Rake: And Other Family Dilemmas.

In the Spiel, ’tis time for a Lobstar of the Antentwig (right after a response to some sexist tweets).

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The Gist - #MeToo and McYoga

On The Gist, comparing Bill Clinton to basketball great Michael Jordan.

Bikram Choudhury’s status as a star yoga guru gave him license to be odd (spiritual but with a soft spot for luxury cars, and always wearing a Speedo). But there was more to it than quirkiness, as sexual assault allegations beginning in 2013 basically expelled Choudhury from the United States. ESPN’s Julia Henderson practiced Bikram Yoga, before capturing the rise and fall of its founder in a five-part podcast: Bikram.

In the Spiel, punning on some of the weirder names in the news these days.

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The Gist - James Clapper: Yeah, Russia Swung the Election

On The Gist, IHOP is changing its name to IHOb. And Mike is here to make fun of that.

James Clapper was a senior intelligence adviser for both Republican and Democratic administrations. He was also part of the team that informed President-elect Donald Trump of Russian interference in the 2016 election. Now, as a private citizen, Clapper says he believes Russia actually swung the vote. “That’s why you write books,” says Clapper. “Because you can express your opinions freely. And I did.” His latest is Facts and Fears: Hard Truths From a Life in Intelligence.

In the Spiel, our expectations of a first lady are sexist and constricting. Cut Melania Trump some slack for not fitting into them.

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The Gist - So You Think You Know About Race

On The Gist, at this point, whatever the Trump administration doesn’t say under oath is very possibly untrue.

In 1963, Robert F. Kennedy met with black America’s greatest artists and intellectuals to talk about race. “And they lit his ass up,” according to our guest, making known just how much needed to be done to address racial inequality. Michael Eric Dyson wrote a book about the encounter and its relevance to race issues today. Dyson’s book is What Truth Sounds Like.

In the Spiel, Miss America is scrapping its swimsuit competition, instantly making the United States perfectly meritocratic. Wait, not really.

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The Gist - Shots Fired, but Not Really

On The Gist, no matter how well the economy goes, pundits can always tell a scary story.

What do we get wrong about Darwinism? Evolutionary ornithologist Richard O. Prum says the theory was distorted by Victorian prudes. He explains why a closer look at bird sex shows us what’s really going on with adaptation and natural selection. Prum’s book is The Evolution of Beauty.

In the Spiel, yes, “unindictable” would mean the president could commit any crime he wants, even the colorful ones. But let’s not get carried away.

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Start the Week - Arundhati Roy on castes and outcasts

Booker Prize-winning novelist Arundhati Roy's latest book weaves together the lives of the misfits and outcasts from India's bustling streets. Roy is famous as an advocate for the most vulnerable and dehumanised in Indian society. She tells Andrew Marr how her main character Anjum builds a small paradise for the dispossessed in a graveyard in Delhi.

Ivan Mishukov walked out of his Moscow flat aged four and spent two years living on the city streets, where he found a home among a pack of wild dogs. Playwright Hattie Naylor used this true and extraordinary story as the basis for a play and now a film, Lek and the Dogs. She explores how the human world failed to look after the child, but how his kindness won the trust and protection of street dogs.

Damian Le Bas grew up surrounded by Gypsy history from his great grandmother. He sets out on the road to discover Travellers' stopping places and to understand how the romanticised stories of the past were replaced by the critical, outcast image of present-day Gypsies.

The columnist and Conservative Peer Daniel Finkelstein appears to be the ultimate establishment insider. But his parents were refugees who were forced to move across Europe because of antisemitism. He believes their desire for rootedness and belonging underlines his own politics.

Producer: Katy Hickman

Picture: Arundhati Roy (credit Mayank Austen Soofi).