Start the Week - The Building Blocks of Life and Intelligence

On Start the Week Anne McElvoy talks to the geneticist Alison Woollard about the extraordinary developments in biological science in the last decade, and how switching on and off certain genes could improve and extend life. The psychologist Kathryn Asbury studies the vexed question of nature and nurture, and whether a better understanding of genetic influence can improve children's education. Professor Roger Kneebone explains the role of jazz improvisation in the operating theatre, and what recreating surgery from the 1980s can teach modern clinicians. Raiding the past for hidden gems fascinates the conductor Sir Mark Elder as he prepares to bring operatic rarities to a new audience.

Producer: Katy Hickman.

Start the Week - Landscape and Community

Bridget Kendall talks to Patrick Keiller about the relationship between film, cities and landscape. Victoria Henshaw is interested in what our cities smell like, and what we lose when we sterilise our environment. The poet Robin Robertston has written about the bleak, remote island of St Kilda and how the remnants of its close-knit community left together in 1930. The importance and difficulty of creating a sense of community is at the heart of Giles Fraser's new series which asks whether we've become merely nostalgic for a bygone age of close neighbourhoods, or whether it's possible to reconstruct them.

Producer: Natalia Fernandez.

Start the Week - Bianca Jagger on human rights

Tom Sutcliffe looks at the future of human rights with the campaigner Bianca Jagger and academic Stephen Hopgood. Jagger points to the failure of the global community to tackle violence against women and girls, while Hopgood sounds the death knell for international Human Rights with the rise of religious conservatism and the decline in influence of Europe and America. Pakistan's Tribal Area close to Afghanistan is the setting for Fatima Bhutto's debut novel, and the playwright Howard Brenton examines the chaos of the partition of India in his latest production, Drawing The Line.

Producer: Katy Hickman.

Start the Week - Gandhi’s Early Years

Bridget Kendall looks back at the formative years of Gandhi with the historian Ramachandra Guha and opera director Phelim McDermott. At the turn of the twentieth century Gandhi spent more than twenty years in South Africa and England: Guha argues that these early experiences shaped his future ideas, while McDermott stages Gandhi's spiritual progress towards nonviolent protest in his production of the opera Satyagraha. Gandhi returned to India just after the outbreak of the First World War and the international historian David Reynolds looks at the legacy of the Great War, and its impact on the decision-makers of the future. The Editor of Prospect Magazine, Bronwen Maddox, explores its legacy.

Producer: Katy Hickman.

Start the Week - Andrew Marr on poet George Herbert

Andrew Marr returns to Start the Week for a special programme on the early 17th century poet George Herbert. His English poetry was never published in his lifetime, but he hoped it would act as consolation 'of any dejected poor soul', and his latest biographer John Drury argues that with its focus on love over theology, his poetry still speaks to and for modern readers. The composer Sir John Tavener and the writer Jeanette Winterson discuss prayer in a secular age, and the power of music and words to soothe the soul.

This programme was recorded before the sad announcement of Sir John Tavener's death.

Producer: Katy Hickman.

Start the Week - Fiona Shaw; Simon McBurney; Journeys Into the Unknown

Stephanie Flanders contemplates nothing with science editor Jeremy Webb who is fascinated with the idea of vacuum, voids and absolute zero; and astronomer Carolin Crawford explains there's more to black holes than meets the eye. The director Simon McBurney looks to reveal all in his production of the Magic Flute, including liberating the orchestra from the pit to centre stage; and Fiona Shaw asks 'is this all?' in her re-imagining of Britten's The Rape of Lucretia.

Producer: Natalia Fernandez.

Start the Week - The Kremlin: A fortress that has shaped a nation

Start the Week is at the Radio 3 Free Thinking Festival in Gateshead. Anne McElvoy talks to the historian Catherine Merridale about the Kremlin - a Russian fortress which has retained its original medieval function to intimidate and control, and which holds a special place in the imagination. Few buildings in England inspire such fear, but Simon Thurley explores how the country's architecture has influenced the world. The Newcastle-born writer Michael Chaplin looks to the history of the River Tyne to understand the changing fortunes of the city and its population; and the Indian writer Amit Chaudhuri attempts to save the remnants of Calcutta's colonial past under its ever-changing skyline. Producer: Katy Hickman.

Start the Week - Paul Collier on Immigration Controls

On Start the Week Stephanie Flanders asks the head of the British Red Cross, Sir Nick Young, whether the charity's principle of neutrality is still as relevant today as it was 150 years ago. The journalist Lindsey Hilsum has reported on the major international conflicts and atrocities in the last few decades and wrestles with the moral complexities of being neutral and impartial. Making judgements about who deserves to be helped and how many, concerns the economist Paul Collier, as he attempts to defuse the explosive subject of immigration. And the Conservative MP Kwasi Kwarteng proposes selling working visas to the highest bidder. Producer: Katy Hickman.

Start the Week - Grayson Perry on contemporary art

Tom Sutcliffe discusses the role and place of contemporary art in today's global, digital world with the artist Grayson Perry. While the Director of Tate Britain Penelope Curtis looks back to a time when images held such power and caused such outrage that they had to be destroyed, in an exhibition on iconoclasm. Philip Davis offers a defence of the value of reading serious literature. And Nicholas Lovell looks at the money that artists can make, using the internet to change the way they relate to their fans. Producer: Katy Hickman.

Start the Week - Victorian Revivalism

Anne McElvoy looks back to the Victorian age with Simon Heffer who argues it laid the foundations for modern society, from the evolution of British democracy, to new attitudes to education, religion and science. Professor of British Government, Anthony King, considers if the blunders of today's parliamentarians has anything on the antics of Gladstone and Disraeli. But the writer DJ Taylor believes it's the era's novels which have left a lasting impression. And the curator Sonia Solicari has created a miscellany of curiosities in her exhibition of contemporary artists influenced and inspired by Victoriana.

Producer: Katy Hickman.