Big Technology Podcast - Anthropic CEO Dario Amodei: AI’s Potential, OpenAI Rivalry, GenAI Business, Doomerism

Dario Amodei is the CEO of Anthropic. He joins Big Technology Podcast for a raw, unfiltered conversation about AI's potential, its stakes, and the source of his outspokenness. The interview is part of a major Big Technology profile about Amodei, ft. interviews with more than two dozen of his colleagues, friends, and critics. You can read that story for free here: https://www.bigtechnology.com/p/the-making-of-dario-amodei

We also cover Mark Zuckerberg's AI talent spending spree, Amodei's rivalry with OpenAI, his response to NVIDIA CEO Jensen Huang's criticism, the state of the AI scaling laws, and whether there's a risk we'll lose control of the technology.

Tune in for a candid, emotional, and high energy conversation with one of the leaders driving the AI wave today.

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Audio and Video by Matt Breetzke of Fireside Visuals: https://www.firesidevisuals.com/

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Code Story: Insights from Startup Tech Leaders - The Gene Simmons of Data Protection – Navigating the Future of Data Management

The Gene Simmons of Data Protection: Protegrity's KISS Method

Today, we are releasing another episode from our series, entitled The Gene Simmons of Data Protection - the KISS Method, brought to you by none other than Protegrity. Protegrity is AI-powered data security for data consumption, offering fine grain data protection solutions, so you can enable your data security, compliance, sharing and analytics.

Episode Title: Navigating the Future of Data Management: Type Systems, Quantum Computing, and Protegrity's Innovations

In our final episode, we are speaking with Michael Howard, CEO of Protegrity. We talk about how traditional type systems often fail short in modern data management, as well as potential threats posed by quantum computing to current encryption methods, as well as how Protegrity's product embeds context and security into the data itself, in order to repel any threat.

Questions

  • Tell me and my audience a little bit about you. 
  • I know that you’ve referred to type systems as “lame.” Can you explain the concept of type systems in databases, why they’re lame, and why they pose challenges for modern data management?
  • How is quantum computing poised to impact the current landscape of data security and encryption?
  • What are some of the limitations of traditional type systems in databases, and how can they be improved to handle modern data challenges?
  • Can you share insights on how Protegrity's approach to data classification and protection differs from traditional methods?
  • Looking ahead, how do you envision the role of type systems evolving with the advent of quantum computing and other emerging technologies?
  • One of Protegrity’s talking points has been how far behind legislation for data privacy and security is compared to today’s rapidly accelerating data landscape. What do you think needs to happen – in quantum and AI – for conversations to turn into action?

Links




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Code Story: Insights from Startup Tech Leaders - S11 E10: Brennan Pothetes, Infinity Constellation

Brennan Pothetes grew up in Louisiana, but went to High School in Portland, Oregon - two very different places. He started his career in internal audit, before he eventually helped launch Simple, the first bank on the iPhone. He has built a lot of companies since, and continues to do so. Outside of business and tech, he likes food and enjoys whipping up some cajun or greek cuisine. Recently, he picked up surfing, but also likes to sit down with real time strategy games like Civilization.

Brennan was one of the first customers of Invisible, which was one of the biggest trainers of LLMs. After he sold his last company, he was approached by the board to help then spin businesses out, but in a strategic way with a hold co, allowing them to work together with them zero to one, and beyond.

This is the creation story of Infinity Constellation.

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Python Bytes - #442 Cloud bills in scientific notation

Topics covered in this episode:
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About the show

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Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Monday at 10am PT. Older video versions available there too.

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Brian #1: Open Source Security work isn't “Special”

  • Seth Larson
  • It seems like security is special in a sense that we don’t want just anyone working on the security aspect of a project. We just want the trusted maintainers, right?
  • Seth is arguing that this is the wrong mindset
  • It makes more sense that we maybe have security experts contribute to many projects, and that someone working on security for just one project doesn’t benefit from scale.
    • “Maintainers don’t see how other projects are triaging vulnerabilities and can’t learn from each other. They can’t compare notes on what they are seeing and whether they are doing the right thing. Isolation in security work breeds a culture of fear. Fear of doing the wrong thing and making your users unsafe.”
    • “These “security contributors” could be maintainers or contributors of other open source projects that know about security, they could be foundations offering up resources to their ecosystem, or engineers at companies helping their dependency graph.”
  • But how do we build trust in these individuals?
    • Meeting in person works.
    • But there are other ways as well.
  • I’d personally love to have someone contact me about a project of mine regarding a security problem or process that the project could/should follow. Especially if I could see other projects I trust already trusting this individual to work on the other projects.

Michael #2: uv v0.8

  • Changes
    • Install Python executables into a directory on the PATH
    • Register Python versions with the Windows Registry
    • Prompt before removing an existing directory in uv venv
    • Bump --python-platform linux to manylinux_2_28
    • Make uv_build the default build backend in uv init
    • And many more
  • And uv v0.8.1
  • And uv v0.8.2
  • And uv v0.8.3
    • Adds Add CPython 3.14.0rc1

Brian #3: Extra, Extra, Extra

Michael #4: Announcing Toad - a universal UI for agentic coding in the terminal

  • by Will McGugan
  • A universal front-end for AI in the terminal.
  • Watch the video.

Joke: Heaviest objects in the universe

And … Cloud Architects 2025 “They send us our cloud bills in scientific notation… “ 🙂

The Government Huddle with Brian Chidester - 190: The One with the Organizational Change Management Expert

Richard Carson, author of the best-seller The Book of Change and an experienced public sector leader joins the show to explore the evolving landscape of organizational change management. Drawing on over 30 years of experience across local, regional, and state government, he shares why effective change isn’t about technology alone—but how organizations adopt and adapt around it. From the bureaucratic hurdles of public service to the psychological toll of transformation, the conversation digs into why most change initiatives fail—and how a bottom-up, empathetic approach can drive lasting impact.

array(3) { [0]=> string(65) "https://mcdn.podbean.com/mf/web/5i7wxtrt6dniicpx/Carson_Final.m4a" [1]=> string(0) "" [2]=> string(8) "28004111" }

Big Technology Podcast - Countdown to GPT-5, OpenAI’s Stargate Sputters, AI Math Wars

Financial Times San Francisco Bureau Chief Stephen Morris joins for our weekly discussion of the latest tech news. We cover: 1) Is GPT-5 really on its way? 2) GPT-5's reported capabilities 3) Is Sam Altman going to call GPT-5 AGI? 4) If GPT-5 codes well, where does that leave Anthropic? 5) Stargate hasn't made a single data center deal yet 6) Scaling Laws back in vogue? 7) AI math olympiad faceoff 8) AI data centers energy costs 9) Google's impressive earnings 10) Tesla's dark outlook 11) Satya Nadella addresses Microsoft's morale after layoffs

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The Stack Overflow Podcast - Saving the world with speed and at scale

The Speed & Scale Plan is a global initiative to move leaders to act on the climate crisis, tracking progress towards net zero by 2050. 

Explore Speed & Scale’s resources for combating climate change, and connect with Ryan on LinkedIn and X.  

Congratulations to Stellar Answer badge winner Christian C. Salvadó who won the badge for answering the question What's a quick way to comment/uncomment lines in Vim?.

Code Story: Insights from Startup Tech Leaders - S11 Bonus: Ben Lerner, Espresso AI

Ben Lerner was a fan of tech growing up, along side being into math and science. Right out of school, he joined a startup called Data Nitro, which attempted to integrate python into excel. Ever since then, he has been jamming in the tech and startup world. Outside of tech, he married to a computational biologist. He enjoys padel, which is kind of like Pickleball meets Tennis, and of course ping pong. Though, with his full time job as a CEO, he often finds his hobby is going home to write code.

Ben realized that LLMs are really good at understanding code, leaps and bounds better than prior ML models. While he was at Google, he was also digging into how to apply LLMs to coding in general. Applying both of these things, he and his co-founders are seeing where this can be applied to the real world, starting with Snowflake compute.

This is the creation story of Espresso AI.

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Lex Fridman Podcast - #475 – Demis Hassabis: Future of AI, Simulating Reality, Physics and Video Games

Demis Hassabis is the CEO of Google DeepMind and Nobel Prize winner for his groundbreaking work in protein structure prediction using AI.
Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep475-sc
See below for timestamps, and to give feedback, submit questions, contact Lex, etc.

CONTACT LEX:
Feedback – give feedback to Lex: https://lexfridman.com/survey
AMA – submit questions, videos or call-in: https://lexfridman.com/ama
Hiring – join our team: https://lexfridman.com/hiring
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EPISODE LINKS:
Demis’s X: https://x.com/demishassabis
DeepMind’s X: https://x.com/GoogleDeepMind
DeepMind’s Instagram: https://instagram.com/GoogleDeepMind
DeepMind’s Website: https://deepmind.google/
Gemini’s Website: https://gemini.google.com/
Isomorphic Labs: https://isomorphiclabs.com/
The MANIAC (book): https://amzn.to/4lOXJ81
Life Ascending (book): https://amzn.to/3AhUP7z

SPONSORS:
To support this podcast, check out our sponsors & get discounts:
Hampton: Community for high-growth founders and CEOs.
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AG1: All-in-one daily nutrition drink.
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OUTLINE:
(00:00) – Introduction
(00:29) – Sponsors, Comments, and Reflections
(08:40) – Learnable patterns in nature
(12:22) – Computation and P vs NP
(21:00) – Veo 3 and understanding reality
(25:24) – Video games
(37:26) – AlphaEvolve
(43:27) – AI research
(47:51) – Simulating a biological organism
(52:34) – Origin of life
(58:49) – Path to AGI
(1:09:35) – Scaling laws
(1:12:51) – Compute
(1:15:38) – Future of energy
(1:19:34) – Human nature
(1:24:28) – Google and the race to AGI
(1:42:27) – Competition and AI talent
(1:49:01) – Future of programming
(1:55:27) – John von Neumann
(2:04:41) – p(doom)
(2:09:24) – Humanity
(2:12:30) – Consciousness and quantum computation
(2:18:40) – David Foster Wallace
(2:25:54) – Education and research

PODCAST LINKS:
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