Category: ScienceNews

A new drug for Alzheimer's disease, called lecanemab, got a lot of attention earlier this year for getting fast-tracked approval based on a clinical trial that included nearly 1,800 people. It was the most diverse trial for an Alzheimer's treatment to date, but still not enough to definitively say if the drug is effective for Black people. "[In] the world's most diverse Alzheimer's trial, a giant trial of 1,800 people that lasted for a much longer time than most trials did, we're still not sure that all of the groups that are at highest risk of Alzheimer's disease actually see any kind of benefit," says Dr. Jonathan Jackson, Assistant Professor of Neurology at Harvard Medical School.

On today's episode, Jonathan and Short Wave co-host Emily Kwong delve into how drug developers can overlook those hardest hit by the disease they're trying to treat.

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We meet experts at the Human Genome Editing Summit in London, seeking to cure genetic disease and ensure that it is safe and available to all.

Roland Pease hears from Victoria Gray, the first person to be cured of the debilitating and life-shortening disease sickle cell anaemia by gene editing, and from the scientists making it possible.

Also, the prospect of work to attempt gene rescue in fetuses before they are born. But the technology is expensive and complex. The question troubling the participants is to ensure people across the world can benefit from it, not just the rich and privileged.

And what are the limitations of gene editing? Can it be made more effective, safer? And what of gene edits that will be inherited by future generations?

Reading the science headlines this week, we have A LOT of questions. Why are more animals than just humans saddled — er, blessed — with vocal fry? Why should we care if 8 million year old plankton fossils are in different locations than plankton living today? And is humanity finally united on protecting the Earth's seas with the creation of the Biodiversity Beyond National Jurisdiction treaty? Luckily, it's the job of the Short Wave team to decipher the science behind the headlines. This week, that deciphering comes from co-hosts Emily Kwong and Aaron Scott, with the help of NPR climate correspondent Lauren Sommer. Hang out with us as we dish on some of the coolest science stories in this ocean-themed installment of our regular newsy get-togethers!

Have suggestions for what we should cover in our next news round up? Email us at shortwave@npr.org.

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Human Genome Editing: The team meet experts at the Human Genome Editing Summit in London, seeking to cure genetic disease and ensure that it's safe and available to all. Roland Pease hears from Victoria Gray, the first person to be cured of the debilitating and life-shortening disease sickle cell anaemia by gene editing, and from the scientists making it possible. Also, the prospect of work to attempt gene rescue in fetuses before they are born. But the technology is expensive and complex – the question troubling the participants is to ensure people across the world can benefit from it, not just the rich and privileged. And what are the limitations of gene editing? Can it be made more effective, safer? And what of gene edits that will be inherited by future generations?

Have you ever wondered how biologists choose what animal to use in their research? Since scientists can't do a lot of basic research on people, they study animals to shed light on everything from human health to ecosystems to genetics. And yet, just a handful of critters appear over and over again. Why the mouse? Or the fruit fly? Or the zebrafish?

Cassandra Extavour, an evolutionary biologist at Harvard, talked with Short Wave co-host Aaron Scott about her favorite new model critter on the block: crickets. (Well, "favorite" might be a strong word. As Cassandra concedes, "to be honest, my opinion about crickets is sort of neutral to slightly grossed out.")

On today's episode we leave the mouse to its maze, and instead consider the cricket and all the amazing things it can teach us.

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The whitebark pine is a hardy tree that grows in an area stretching from British Columbia, Canada south to parts of California and east to Montana. It's a keystone species in its subalpine and timberline ecosystems and plays an outsized role in its interactions with other species and the land — feeding and providing habitat for other animals, and providing shade to slow glacial melt to the valleys below. But it's increasingly threatened — by more intense fires, by mountain pine beetle infestations and by a deadly fungus called blister rust. Today, producer Berly McCoy takes the microphone to share the ongoing efforts by reforestation forester ShiNaasha Pete and others to save this important species.

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Indonesia is the world's largest exporter of coal for electricity. And it's also an emerging economy trying to address climate change. The country recently signed a highly publicized, $20 billion international deal to transition away from coal and toward renewable energy. The hope is the deal could be a model for other countries. But Indonesian energy experts and solar executives worry much of this deal may be "omong kosong" — empty talk. Today, NPR climate solutions reporter Julia Simon breaks down the realities and limitations of Indonesia's renewable aspirations.

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The Roman Colosseum is a giant, oval amphitheater built almost two thousand years ago. Despite its age and a 14th century earthquake that knocked down the south side of the colosseum, most of the 150-some foot building is still standing. Like many ancient Roman structures, parts of it were constructed using a specific type of concrete. Scientists and engineers have long suspected a key to these buildings' durability is their use of this Roman concrete. But exactly how this sturdy concrete has contributed to the architecture's strength has been a mystery to researchers across the globe.

A team of interdisciplinary researchers have recently discovered one answer to why these ancient Roman buildings have weathered the test of time — while many modern, concrete structures seem to crumble after a few decades.

The answer: self-healing concrete.

Curious about other new discoveries or potential climate solutions scientists are researching? Email us at ShortWave@NPR.org.

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The long rains of East Africa are forecast to fail again, for the third year running, precipitating a food crisis affecting millions. Science In Action explores the science of the drought, hears about new methods improving forecasts, and what is unusual about the region that makes it so vulnerable.

When we think of helium, for many of us balloons and squeaky voices come to mind. But the noble gas is critical for many aspects of modern life – and we’re facing a global shortage. Dr Annie Cheng and her colleagues at the University of Oxford are attempting to solve this by creating a model that has the potential to locate previously untapped reservoirs.

CrowdScience listener Eric, in New Zealand, has noticed his wisteria growing towards a neighbouring tree. He thinks that it actually knows where it’s going. But how can a plant have a sense of direction?

Plants don’t have the advantage of brains or eyes, but that doesn’t seem to stop them from being clever enough to find out from their environment where to move and how to get there – all while being rooted to the spot.

Marnie Chesterton visits the Natural History Museum and Kew Gardens in London, home to the largest collection of living plants in the world, to discover how plants make their manoeuvres, and talks to botanists and plant biologists for the latest findings on the mysterious life of climbing plants.

Image by Gerald Anderson/Anadolu Agency via Getty Images

Producer: Roland Pease Assistant Producer: Sophie Ormiston

CrowdScience listener Eric, in New Zealand, has noticed his wisteria growing towards a neighbouring tree. He thinks that it actually knows where it’s going. But how can a plant have a sense of direction?

Plants don’t have the advantage of brains or eyes, but that doesn’t seem to stop them from being clever enough to find out from their environment where to move and how to get there – all while being rooted to the spot.

Marnie Chesterton visits the Natural History Museum and Kew Gardens in London, home to the largest collection of living plants in the world, to discover how plants make their manoeuvres, and talks to botanists and plant biologists for the latest findings on the mysterious life of climbing plants.

Featuring:

Dr Mariane Sousa-Baena, School of Integrative Plant Sciences, Cornell University Dr Ilia Leitch, Senior Research Leader, Kew Gardens Tom Freeth, Head of Plant Records, Kew Gardens Dr Silvia Guerra, Neuroscience of Movement Laboratory, Padua University Professor Christian Fankhauser, Centre for Integrative Genomics, Lausanne University Dr Sandra Knapp, Merit Researcher, Natural History Museum