Short Wave - Killer Proteins: The Science Of Prions

Prions are biological anomalies – self-replicating, not-alive little particles that can misfold into an unstoppable juggernaut of fatal disease. Prions don't contain genes, and yet they make more of themselves. That has forced scientists to rethink the "central dogma" of molecular biology: that biological information is always passed on through genes. The journey to discovering, describing, and ultimately understanding how prions work began with a medical mystery in a remote part of New Guinea in the 1950s. The indigenous Fore people were experiencing a horrific epidemic of rapid brain-wasting disease. The illness was claiming otherwise healthy people, often taking their lives within months of diagnosis. Solving the puzzle would help unlock one of the more remarkable discoveries in late-20th-century medicine, and introduce the world to a rare but potent new kind of pathogen. For the first episode in a series of three about prion disease, Short Wave's Gabriel Spitzer shares the science behind these proteins with Emily Kwong, and explains why prions keep him awake at night.

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Short Wave - Where Do Climate Negotiations Stand At COP27?

Climate negotiations continue at COP27 in Sharm el-Sheikh, Egypt. Tens of thousands of attendees from around the world have gathered in the seaside resort town. They've come to discuss some of the key issues to figure out how to combat climate change, remedy its effects, and to focus on implementing the big changes discussed last year in Glasgow.

Correspondent Nathan Rott joins Emily Kwong to walk through the biggest debates at this year's COP, like loss and damage payments. And, he talks about how the war in Ukraine and the U.S. midterm elections are affecting discussions as well.

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Short Wave - Searching For A New Life

Today, we pass the mic to our colleagues at All Things Considered to share the first piece in their series on the impact of climate change, global migration and far-right politics. They begin with the story of Mamadou Thiam, a Senegalese man living in a temporary shelter created by the United Nations. He is from a family of fishermen, but floods have destroyed his home. In the past when there was flooding, people could relocate for a few months and then return. But more flooding means leaving may become permanent.

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Short Wave - Corey Gray Is Picking Up Cosmic Vibrations

A pivotal week in Corey Gray's life began with a powwow in Alberta and culminated with a piece of history: the first-ever detection of gravitational waves from the collision of two neutron stars. Corey was on the graveyard shift at LIGO, the Laser Interferometer Gravitational Observatory in Hanford, Washington, when the historic signal came. Corey tells Short Wave Scientist in Residence Regina G. Barber about the discovery, the "Gravitational Wave Grass Dance Special" that preceded it, and how he got his Blackfoot name.

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Unexpected Elements - Neurons that restore walking in paralysed patients

Researchers have identified which neurons, when electrically stimulated, can restore the ability to walk in paralysed patients. Professor Jocelyne Bloch, Associate Professor at the Université de Lausanne, tells Roland how the technology works.

Astronomers have discovered the closest black hole to Earth. Researchers led by Kareem El-Badry, astrophysicist at Harvard University, identified the celestial body when they spotted a Sun-like star orbiting a dark, dense object.

The origins of eels have been mystifying scientists for centuries. Though the Sargasso Sea has been their presumed breeding place for 100 years, there has been no direct evidence of their migration – until now. Ros Wright, Senior Fisheries Technical Specialist at the Environment Agency, shares how researchers finally pinned down these slippery creatures.

This week, a new report from the UN Environment Programme reveals that carbon dioxide emissions from building operations have reached an all-time high. Insaf Ben Othmane, architect and co-author of the report, talks through the risks and opportunities this poses for Africa and why there is still hope for the future.

After learning how long it will take the Earth's ice sheets to melt in the previous episode, we continue our journey in Greenland. As world leaders gather in Egypt for the annual UN climate conference, listener Johan isn't too optimistic about governments' ability to curb greenhouse gas emissions and get a handle on climate change. So from his coastal perch in Denmark, he's asked where we should live when the poles have melted away and coastlines creep inland.

Along with the help of BBC correspondents around the world, Marnie Chesterton scours the globe for the best option for listener Johan's new home. From high-up, cold desert regions to manmade islands, Marnie's on a mission to find a climate-proof destination. But as we hear from climate scientists, we might not be the only ones on the move, and waters aren't going to rise evenly around the world. Can Marnie find a place to go, away from the expanding seas?

(Image: Patient with complete spinal cord injury (left) and incomplete spinal cord injury (right) walking in Lausanne. Credit: Jimmy Ravier/NeuroRestore)

CrowdScience - Where do we go when the seas rise?

After learning how long it will take the Earth's ice sheets to melt in the previous episode, we continue our journey in Greenland. As world leaders gather in Egypt for the annual UN climate conference, listener Johan isn't too optimistic about governments' ability to curb greenhouse gas emissions and get a handle on climate change. So from his coastal perch in Denmark, he has asked where we should live when the poles have melted away and coastlines creep inland.

Along with the help of BBC correspondents around the world, Marnie Chesterton scours the globe for the best option for listener Johan's new home.

BBC Mundo reporter Rafael Rojas takes us to a manmade island off Colombia's Caribbean coast to see how we might be able to live with the seas. Meanwhile, reporter Furkan Khan takes us into the high, cold desert region of Ladakh to see if heading for the hills might be the answer.

As Marnie searches for a climate-proof destination, she speaks to conservation biogeographer Matt Fitzpatrick, from the Appalachian Laboratory at the University of Maryland Center for Environmental Science. He's made a map that shows what towns and cities will feel like in 60 years and where you should visit in order to get a preview of your home's future climate. But Matt also tells us that we might not be the only ones on the move.

And as climate scientist Ruth Mottram from the Danish Meteorological Institute tells us, waters are not going to rise evenly around the world. So can Marnie find a place to go, away from the expanding seas?

Additional contributors: Alexander Atencio, environmental sustainability teacher, Santa Cruz del Islote, Colombia Sebastian Martinez, local leader, Santa Cruz del Islote, Colombia Professor Mohammad Din, Ladakh Environment and Health Organisation Ellen and Carl Fiederickson, teacher and sheep farmers, Qassiarsuk, Greenland

Presenter: Marnie Chesterton Producer: Sam Baker

Short Wave - Climate Tipping Points And The Damage That Could Follow

If Earth heats up beyond 1.5 degrees, the impacts don't get just slightly worse--scientists warn that abrupt changes could be set off, with devastating impacts around the world. As the 27th annual climate negotiations are underway in Egypt and the world is set to blow past that 1.5°C warming threshold,
Emily Kwong talks to climate correspondents Rebecca Hersher and Lauren Sommer about three climate tipping points--points of no return that could cause big changes to the Earth's ecosystems.

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Science In Action - Neurons that restore walking in paralysed patients

Researchers have identified which neurons, when electrically stimulated, can restore the ability to walk in paralysed patients. Professor Jocelyne Bloch, Associate Professor at the Université de Lausanne, tells Roland how the technology works.

Astronomers have discovered the closest black hole to Earth. Researchers led by Kareem El-Badry, astrophysicist at Harvard University, identified the celestial body when they spotted a Sun-like star orbiting a dark, dense object.

The origins of eels have been mystifying scientists for centuries. Though the Sargasso Sea has been their presumed breeding place for 100 years, there has been no direct evidence of their migration – until now. Ros Wright, Senior Fisheries Technical Specialist at the Environment Agency, shares how researchers finally pinned down these slippery creatures.

This week, a new report from the UN Environment Programme reveals that carbon dioxide emissions from building operations have reached an all-time high. Insaf Ben Othmane, architect and co-author of the report, talks through the risks and opportunities this poses for Africa and why there is still hope for the future.

Producer: Roland Pease Assistant Producer: Sophie Ormiston

(Photo: Patient with complete spinal cord injury (left) and incomplete spinal cord injury (right) walking in Lausanne. Credit: Jimmy Ravier/NeuroRestore)

Short Wave - Depression And Alzheimer’s Treatments At A Crossroads

Researchers are launching a make-or-break study to test the conventional wisdom about what causes Alzheimer's disease. And in a recent small study, the antidepressant effects of ketamine lasted longer when an intravenous dose was followed with computer games featuring smiling faces or words aimed at boosting self-esteem. As science correspondent Jon Hamilton heads to the Society for Neuroscience's annual meeting, he talks to Aaron Scott about his most recent reporting on depression and Alzheimer's, and previews what he'll be talking to researchers about at the meeting.

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