Short Wave - The Past, Present and Future of mRNA Vaccines

The Pfizer-BioNTech and Moderna COVID-19 vaccines are the first authorized vaccines in history to use mRNA technology. The pandemic might've set the stage for their debut, but mRNA vaccines have been in the works for more than 30 years. Host Maddie Sofia chats with Dr. Margaret Liu, a physician and board chair of the International Society for Vaccines, about the history and science behind these groundbreaking vaccines. We'll also ask, what we can expect from mRNA vaccines in the future?

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Unexpected Elements - Africa’s oldest burial

Analysis of the 78,0000-year-old fossil of a Kenyan boy reveals he was likely buried with care and attention, the body wrapped and laid to rest supported on a pillow. Maria Martinon-Torres, of the National Research Centre on Human Evolution in Burgos, Spain, and a team from Kenya and Germany used techniques from paleontology and forensic science to reveal his story from the fragile remains.

A promising malaria vaccine is to enter trials which could lead to it being used globally to vaccinate children. Merheen Datoo, Oxford University’s Jenner Institute, explains malaria vaccines have been in development for 100 years. Research from these helped covid vaccine development and the success of covid vaccines may now help to speed up the rollout of malaria vaccines.

Covid vaccines may also help to treat those who have symptoms of long covid – a range of immune system issues that develop sometimes months after the initial infection. Yale University immunologist Akiko Kawasaki is embarking on a research project to assess the impact. If you’d like to take part, have yet to be vaccinated, and live in Connecticut in the US, email covidrecovery@yale.edu.

And in India scientists are calling on the government to make all data on Covid more widely available. At present Indian bureaucracy means statistics on infection rates, variants and recovery are not distributed widely. Science journalist TV Padma says greater access to the data could help more scientists come together to work on solutions to India’s Covid crisis.

And, Have you taken classes to learn a new sport or musical instrument or a language? It’s hard work! Why is it that as children we effortlessly absorb new skills and we don’t as adults?

That’s what 50-something listener Gary Grief wondered about playing guitar. Do you need to play more frequently as an adult to attain the same level of expertise? Does the 10,000-hours theory still apply?

Presenter and budding tabla-player Anand Jagatia embarks on a musical journey to discover what neuroscience can tell us about muscle memory and learning. Do musicians and sportsmen share the same challenges? By understanding what’s happening in the brain, can we learn how to learn better?

With tabla-teacher Satvinder Sehmbey, neuroscientist Dr Jessica Grahn, viola-player Dr Molly Gebrian and sports scientist Prof Yannis Pitsiladis.

(Image: An artist’s interpretation of Mtoto’s burial Credit: Fernando Fueyo)

CrowdScience - Why is learning stuff harder as you get older?

Have you taken classes to learn a new sport or musical instrument or a language? It’s hard work! Why is it that as children we effortlessly absorb new skills and we don’t as adults? That’s what 50-something listener Gary Grief wondered about playing guitar. Do you need to play more frequently as an adult to attain the same level of expertise? Does the 10,000-hours theory still apply? Presenter and budding tabla-player Anand Jagatia embarks on a musical journey to discover what neuroscience can tell us about muscle memory and learning. Do musicians and sportsmen share the same challenges? By understanding what’s happening in the brain, can we learn how to learn better? With tabla-teacher Satvinder Sehmbey, neuroscientist Dr Jessica Grahn, viola-player Dr Molly Gebrian and sports scientist Prof Yannis Pitsiladis. Presented by Anand Jagatia Produced by Dom Byrne for the BBC World Service

[Image: Adult and Child learning Piano. Credit: Getty Images]

Short Wave - ‘Everyone I Know Has Lost Someone’: An Update From India

The numbers are staggering. India has been reporting more than 300,000 COVID-19 cases each day for the past two weeks, and recently topped more than 400,000 cases in a single day, a global record. Many more cases are likely unreported. NPR International Correspondent Lauren Frayer shares the latest from India.

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Science In Action - Africa’s oldest burial

Analysis of the 78,0000-year-old fossil of a Kenyan boy reveals he was likely buried with care and attention, the body wrapped and laid to rest supported on a pillow. Maria Martinon-Torres, of the National Research Centre on Human Evolution in Burgos, Spain, and a team from Kenya and Germany used techniques from paleontology and forensic science to reveal his story from the fragile remains.

A promising malaria vaccine is to enter trials which could lead to it being used globally to vaccinate children. Merheen Datoo, Oxford University’s Jenner Institute, explains malaria vaccines have been in development for 100 years. Research from these helped covid vaccine development and the success of covid vaccines may now help to speed up the rollout of malaria vaccines.

Covid vaccines may also help to treat those who have symptoms of long covid – a range of immune system issues that develop sometimes months after the initial infection. Yale University immunologist Akiko Kawasaki is embarking on a research project to assess the impact. If you’d like to take part, have yet to be vaccinated, and live in Connecticut in the US, email covidrecovery@yale.edu.

And in India scientists are calling on the government to make all data on Covid more widely available. At present Indian bureaucracy means statistics on infection rates, variants and recovery are not distributed widely. Science journalist TV Padma says greater access to the data could help more scientists come together to work on solutions to India’s Covid crisis.

(Image: An artist’s interpretation of Mtoto’s burial Credit: Fernando Fueyo)

Presenter: Roland Pease Producer: Julian Siddle

Short Wave - A Fragile X Treatment May Be On The Horizon

Katie Clapp and Michael Tranfaglia's son was born with a genetic disorder that affects brain development. It makes it hard to learn language and basic daily tasks and often is accompanied by a host of other disorders. To help find a cure, they started a foundation and raised research money. After several setbacks, one treatment is showing promise. NPR neuroscience reporter Jon Hamilton tells Emily Kwong the story.

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Short Wave - Why Some Countries Have Low Vaccination Rates

We've been talking a lot about COVID in the US. Now, we want to look at how things are going in some other countries. NPR's correspondents — Jason Beaubien, Phil Reeves, and Anthony Kuhn — talk with Morning Edition's Noel King about why most of the world is struggling to get even a small percentage of their population vaccinated.

Have questions about the latest coronavirus headlines? Email us at shortwave@npr.org and we might cover it on a future episode.

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Short Wave - A Vaccination Update And The CDC’s Latest Guidance On Masks

The rate of vaccination in the U.S. continues to slow. Maddie Sofia talks with NPR health correspondent Allison Aubrey about that and what can be done to get more people vaccinated. Also, making sense of the CDC's latest mask guidance.

Have questions about the latest coronavirus headlines? Email us at shortwave@npr.org and we might cover it on a future episode.

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Short Wave - Burnout: The Crisis Plaguing Health Care Workers

Today, NPR's mental health correspondent Rhitu Chatterjee guests hosts Short Wave. She talks to Dr. Arghavan Salles about burnout among health care workers — what it looks like, what it's doing to the mental health of doctors and nurses and how institutions can address it.

Have a scientific question you can't stop thinking about? Drop us a line at shortwave@npr.org — we'd love to hear it.

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CrowdScience - Why are seeds such different sizes?

When eating a blackberry one day, CrowdScience listener Charles got a tiny seed stuck in his teeth. That got him wondering: why are seeds the size they are? Why does a blackberry have dozens of tiny pips, while a peach has one huge stone right in the middle?

Plant seeds have been around for hundreds of millions of years, so they’ve had plenty of time to shapeshift into wildly different forms: from dust-like orchid seeds to giant coconuts. This evolution has been a long and intricate dance with wind, water and animals; we ask how different kinds of seeds might respond to today’s environmental threats and rapidly changing ecosystems.

And we go in search of the world’s biggest seed, the coco de mer: native to just two remote islands in the Indian Ocean and weighing up to 18kg, how did this seed evolve to be so much bigger than any other?

With Professor Angela Moles, Dr Si-Chong Chen, Marc Jean-Baptiste, Dr Frauke Fleischer-Dogley and Dr Wolfgang Stuppy.

Presented by Marnie Chesterton Produced by Cathy Edwards for the BBC World Service

[Photo: Different sized fruit seeds. Credit: Getty Images]