Category: ScienceNews

Pain, particularly chronic pain, is hard to research. New therapeutics are hard to screen for. Patients are not all the same. Sergui Pascu and colleagues at Stanford university have been growing brain samples from stem cells. Then they began connecting different samples, specialised to represent different brain regions. This week they announce their most complex “assembloid” yet, one that even reacts to hot chilli, passing a signal from the sensory neurons through to the thinking bits. The hope is that it can provide insights on how pain, and potential painkillers, work.

Human brains are notoriously large, particularly infants. Whilst for primates the human pelvis is quite narrow, to allow us to walk and run on two legs. This notoriously makes childbirth, well, not as straightforward as most other species. This evolutionary “obstetric dilemma” has been debated for decades. Marianne Brasil, of Western Washington University, and colleagues, have published this week a huge study of contemporary human genes and anatomies available from the UK Biobank to shed some more light on this ongoing compromise.

Malta is an island in the Mediterranean no less than 80km from land. So how come Eleanor Scerri and colleagues have discovered archaeological evidence of hunter-gatherers living there from 8,500 years ago? And they didn’t just visit and leave. They stayed for perhaps a millennium before farming arrived. Maybe a rethink of what nautical capabilities our ancestors had in the deep past is needed?

A year ago, Science in Action gate-crashed a conference looking at plans for meeting the forthcoming arrival of asteroid Apophis in 2029. This year the meeting is in Tokyo, and Richard Binzel, emeritus professor of Astronomy at MIT, gives us an update on how the space agencies are hoping to collaborate to maximise the scientific value from what will be a global, visible, phenomenon in just 4 years. Is there enough time to get our collective wits together?

(Image: 3D illustration of Interconnected neurons with electrical pulses. Credit: Getty Images)

Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Josie Hardy

This week, we've heard from researchers trying to untangle the effects of the "trip" that often comes with psychedelics and ketamine from the ways these drugs might change the human brain. For part three of our series on psychedelic drug research, we get a glimpse into why some researchers are taking the "trip" out of these drugs altogether. You don't need to have heard the previous two episodes to understand this episode on what could be next for psychedelic medicine.

Catch the rest of this series on psychedelics and related drugs this week by following us on Spotify and Apple Podcasts. They're the previous two episodes in our podcast feed.

Have other questions about psychedelics and the brain? Let us know by emailing shortwave@npr.org!

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What if you could get all the potential benefits of ketamine without the "trip"? For part two of our series on psychedelics, we look at how some researchers are trying to disentangle the "trip" from the drugs' effects on the brain — and why the answer could help direct the future of psychedelic research. (Spoiler alert: People generally know if they're tripping or not.) This episode: a researcher navigating this challenge by putting his patients to sleep.

Catch the rest of this series on psychedelics and related drugs this week by following us on Spotify and Apple Podcasts.

Have other questions about psychedelics and the brain? Let us know by emailing shortwave@npr.org!

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Researchers are studying psychedelics as a possible treatment for conditions like depression, PTSD and substance use disorders. But they don't know exactly how these drugs work.

Getting the answer to this question is especially difficult when people often take psychedelics like LSD and psilocybin for the "trip."

This week on Short Wave, we're talking to researchers about how they're trying to untangle the effects of this "trip" from the ways psychedelics might change the human brain ... and why the answer could help direct the future of psychedelic research.

Catch the rest of this series on psychedelics and related drugs this week by following us on Spotify and Apple Podcasts.

Have other questions about psychedelics and the brain? Let us know by emailing shortwave@npr.org!

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Artificial, human-made reefs have been deployed around the country to enhance and protect coastlines. The Department of Defense is working to deploy them in waters off its coastal military bases with its “Reefense” project. Ali Rogin speaks with Catherine Campbell, who manages the program, to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders

While ocelots are widespread in South and Central America, in the United States they are on the brink of extinction. They were once overhunted for their coats, and now they face shrinking habitats. Researchers hope that the key to restoring this species can be found in fertility treatments. John Yang reports for our series, “Saving Species.” PBS News is supported by - https://www.pbs.org/newshour/about/funders

What can centuries-old whaling ship logs tell us about today’s extreme weather? According to scientists, the answer is a lot. They’re using the information recorded by mariners going back hundreds of years to push the frontier of modern-day climate science. Special correspondent Pamela Watts with Rhode Island PBS reports. PBS News is supported by - https://www.pbs.org/newshour/about/funders

On the banks of the St Lawrence River in Quebec stands a 100-year-old lighthouse. While initially built to help boats navigate one of Canada’s most difficult waterways, the Point-de-Père site now also holds a different responsibility: it is a key reference for measuring sea levels around the entire North America continent.

But this is all set to change. With the development of new satellite technology, the tricky task of measuring sea levels is being updated - which could mean mountains around North America get brand new official heights.

In this episode we revisit a question from CrowdScience listener Beth, who wondered about the elevation signs she saw scattered along a mountainous road, indicating how high above sea level she was. As sea levels rise, will all the elevation signs need repainting? And how do you measure sea level, anyway?

The height of an enormous pile of rock like Ben Nevis, or Mount Everest feels unchangeable. But we measure them relative to the nearest patch of sea, which is where our story becomes complicated. Unlike water in a bath, sea level is not equal around the world. In fact, nothing on earth - not the sea, the shore or the mountains - is stable or constant, so the question of what you measure from and to becomes incredibly tricky. But that hasn’t stopped scientists risking life and fingers to use an ever-evolving array of technologies to find answers.

Join host Marnie Chesterton as she dives into the mechanics of the latest sea level technology, and how it could make a big difference to understanding our unpredictable world.

Presenter: Marnie Chesterton Producer: Julia Ravey and Marnie Chesterton Editor: Cathy Edwards Production Co-ordinator: Ishmael Soriano and Jana Holesworth Studio Manager: Emma Harth

(Image: Elevation Sign Post, Rocky Mountain National Park. Credit: Stephanie Beverungen via Getty Images.)

On World Rat Day, we’re getting ratty! We look at the biology behind the eternal struggle between rats and rat poison, and we hear about rat-on-rat warfare and other forms of pest control.

We don’t play games when it comes to rats, but we know someone who does. Dr Michael Brecht from the Humboldt University of Berlin tells us how he played hide-and-seek with lab rats and what that tells us about the behaviour of play.

On the topic of ‘rat’ behaviour, we are joined by Dr Zach Berry from the University of Southern California to talk about the psychology behind ratting people out in the workplace, testing the loyalty and morals of the Unexpected Elements team.

And speaking of rats in the workplace… we hear a first-hand report on whether African giant pouched rats might just be better staff members than humans when it comes to detecting tuberculosis at APOPO labs.

All that, plus many more Unexpected Elements.

Presenter: Anand Jagatia, with Tristan Ahtone and Christine Yohannes Producer: Imaan Moin, with Debbie Kilbride, Alice Lipscombe-Southwell, Noa Dowling, Harrison Lewis and Sophie Ormiston. Studio Manager: Cath McGhee

Running an entire marathon takes a lot of energy. Neuroscientist Carlos Matute knows this: he's run 18 of them. He wondered how runners' bodies get the energy they need to make it to the finish line.

His new research in the journal Nature Metabolism may be the first step in answering the question – and suggests their brains might be (temporarily) depleting a fatty substance that coats nerve cells called myelin.

Have other questions about the brain? Let us know by emailing shortwave@npr.org!

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