Category: Series

Martha’s Vineyard has a Lyme disease problem. Now a scientist is coming to town with a possible fix: genetically engineered mice.

An island associated with summer rest and relaxation is gaining a reputation for something else: Lyme disease. Martha’s Vineyard has one of the highest rates of Lyme in the country. Now MIT geneticist Kevin Esvelt is coming to the island with a potential long-term fix. The catch: It involves releasing up to a few hundred thousand genetically modified mice onto the island. Are Vineyarders ready?

Kevin Esvelt makes the case for engineered mice, at a public meeting at a Vineyard public library. (Photo: Annie Minoff)

 

Kevin Esvelt takes questions from the Martha’s Vineyard audience. (He’s joined by Dr. Michael Jacobs and Dr. Sam Telford. (Photo: Annie Minoff)

 

Bob, Cheryl, and Spice (the lucky dog who gets a Lyme vaccine). (Photo: Annie Minoff)

 

No lack of tick-repelling options at a Martha’s Vineyard general store. (Photo: Annie Minoff)

 

(Original art by Claire Merchlinsky)

 

GUESTS

Kevin Esvelt, Assistant Professor, MIT Media Lab

 

FOOTNOTES

Read Kevin Esvelt’s original paper describing the gene drive mechanism in eLife. Less technical descriptions available here via Scientific American, and here via Esvelt’s Sculpting Evolution Group. Watch Kevin’s July 20, 2016 presentation on Martha’s Vineyard (Unfortunately there is no direct link. Search “7.20.16” to find the video, titled “Preventing Tick-Borne Disease.”) Listen to Kevin Esvelt talk about gene drive on Science Friday. Read about Oxitec’s proposed mosquito trial in Key West, and watch the public meeting excerpted in this episode. Learn more about Kevin’s lab, the Sculpting Evolution Group. Looking for more information about Lyme disease? Here are resources from the CDC.

CREDITS

This episode of Undiscovered was reported and produced by Annie Minoff and Elah Feder. Editing by Christopher Intagliata. Fact-checking help by Michelle Harris. Original music by Daniel Peterschmidt. Our theme music is by I am Robot and Proud. Art for this episode by Claire Merchlinsky. Thanks to Science Friday’s Danielle Dana, Christian Skotte, Brandon Echter, and Rachel Bouton.

 

Special thanks to Joanna Buchthal, Bob Rosenbaum, Dick Johnson, and Sam Telford.

 

In the mid 1940s, no one would publish Kurt Vonnegut’s stories. But when he gets hired as a press writer at General Electric, the company’s fantastical science inspires some of his most iconic--and best-selling--novels.

Every snowflake is unique—except they all have six sides. In ice, water molecules arrange themselves into hexagons. (Courtesy MiSci Museum)

Imagine the Earth has been turned into a frozen wasteland. The culprit? Ice-nine. With a crystalline structure that makes it solid at room temperature, ice-nine freezes every drop of water it comes into contact with, and (predictably) ends up destroying the world. This is the fantastical plot of Kurt Vonnegut’s 1963 novel, Cat’s Cradle. But the science that inspired the fiction came from the real-life research his older brother and team of scientists at General Electric conducted just after World War II.

General Electric might be best known for manufacturing refrigerators and light bulbs, but in the 1940s, the GE scientists joined forces with the military and set their sights on a loftier project: controlling the weather.

Controlling the weather could mean putting an end to droughts and raining out forest fires. But the GE scientists’ military collaborators have more aggressive plans in mind. Kurt, a pacifist, closely watches GE’s saga unfold, and in his stories, he demands an answer to one of science’s greatest ethical questions: are scientists responsible for the pursuit of knowledge alone, or are they also responsible for the consequences of that knowledge?

 

Vincent Schaefer of the General Electric Research Laboratory demonstrates his method for making snow in a laboratory freezer, circa 1947.

Vincent Schaefer, colleague of Bernie Vonnegut, makes man-made snow in a freezer at General Electric. (Courtesy of MiSci Museum)

 

Vincent Schaefer gives a demonstration of the team’s cloud seeding research to Signal Corps at GE laboratories in 1947. (Courtesy of MiSci Museum)

  

(Original art by Claire Merchlinsky)

 

GUESTS

Ginger Strand, author of The Brothers Vonnegut: Science and Fiction in the House of Magic Cynthia Barnett, author of Rain: A Natural and Cultural History  

CREDITS

This episode of Undiscovered was reported and produced by Elah Feder and Annie Minoff. Editing by Christopher Intagliata. Archival material was provided with help from Chris Hunter of miSci in Schenectady, as well as Scott Vonnegut and Jim Schaefer. Fact-checking help by Michelle Harris. Voice acting by Charles Bergquist, Christie Taylor, Luke Groskin, and Ira Flatow. Original music by Daniel Peterschmidt. Our theme music is by I am Robot and Proud. Art for this episode by Claire Merchlinsky. Thanks to Science Friday’s Danielle Dana, Christian Skotte, Brandon Echter, and Rachel Bouton.

 

After a senator calls her research a waste of taxpayer dollars, biologist Sheila Patek heads to Capitol Hill to prove what her science is worth.

In December 2015, the fight over science funding got personal for biologist Sheila Patek. She discovered that a U.S. Senator, Jeff Flake of Arizona, had included her research on mantis shrimp in his “wastebook”: a list of federally-funded projects he deemed a waste of taxpayer money. So what did Patek do? She headed to Capitol Hill to make the case to Senator Flake—and to Congress—that blue-sky science is worth the money.

 

GUESTS

Sheila Patek, Professor of Biology, Duke University Bryan Berky, Executive Director, Restore Accountability Paula Stephan, Professor of Economics, Georgia State University, author of How Economics Shapes Science Melinda Baldwin, science historian, author of Making Nature: The History of a Scientific Journal

 

FOOTNOTES

Read Sen. Jeff Flake’s 2015 Wastebook "The Farce Awakens," and his science-themed 2016 Wastebook “Twenty Questions.” Watch two mantis shrimp duke it out! Read Melinda Baldwin’s article on the grand-daddy of the modern waste report: Sen. William Proxmire. Read about Congressman Jim Cooper’s answer to Sen. Proxmire’s “Golden Fleece Award”: the “Golden Goose Award." Read the National Academy of Sciences, Engineering, and Medicine’s 2014 report Furthering America’s Research Enterprise, detailing the benefits of federal science investment (and the difficulty of measuring them). Learn more about Restore Accountability and read their response to the episode. Watch Sheila Patek’s PBS NewsHour essay about her meeting with Sen. Flake, and read about current research at the Patek Lab. How much does the federal government spend on R&D? Here’s how much!

 

CREDITS

This episode of Undiscovered was reported and produced by Annie Minoff and Elah Feder. Editing by Christopher Intagliata. Fact-checking help by Michelle Harris. Original music by Daniel Peterschmidt. Our theme music is by I am Robot and Proud. Art for this episode by Claire Merchlinsky. Thanks to Science Friday’s Danielle Dana, Christian Skotte, Brandon Echter, and Rachel Bouton.

Are you just six handshakes away from every other person on Earth? Two mathematicians set out to prove we’re all connected.

You have probably heard the phrase “six degrees of separation,” the idea that you’re connected to everyone else on Earth by a chain of just six people. It has inspired a Broadway play, a film nerd’s game, called “Six Degrees of Kevin Bacon”...and even a No Doubt song! But is it true? In the ‘90s, two mathematicians set out to discover just how connected we really are—and ended up launching a new field of science in the process.

Annie holds one of Milgram’s “Letter Experiment” mailings sent to June Shields in Wichita, Kansas. Accessed at the Yale University archives. (Credit: Elah Feder)

 

 

A version of psychologist Stanley Milgram’s “Letter Experiment” mailings. “Could you, as an active American, contact another American citizen regardless of his walk of life?” Milgram and his team wrote. They asked for recipients' help in finding out. Accessed at the Yale University archives. (Credit: Elah Feder)

 

(Original art by Claire Merchlinsky)

 

GUESTS

Duncan Watts, Principal Researcher at Microsoft Research, author of Six Degrees: The Science of a Connected Age Steven Strogatz, Jacob Gould Schurman Professor of Applied Mathematics at Cornell University, author of Sync Andrew Leifer, Assistant Professor in the Department of Physics and the Princeton Neuroscience Institute at Princeton University

 

FOOTNOTES

Read Duncan Watts’ and Steven Strogatz’s breakthrough 1998 Nature paper on small-world networks. Read Stanley Milgram’s 1967 article about his letter experiment in Psychology Today. Watch Duncan and Steve discuss the past and future of small-world networks at Cornell. Watch C. elegans' brain glow! And read more about the brain imaging work happening in Andrew Leifer’s lab. Browse the small-world network of C. elegans’ 302 neurons at wormweb.org. Read Facebook’s analysis of Facebook users’ “degrees of separation.” Just for funsies, a network analysis of Game of Thrones.

 

CREDITS

This episode of Undiscovered was reported and produced by Annie Minoff and Elah Feder. Editing by Christopher Intagliata. Fact-checking help by Michelle Harris. Original music by Daniel Peterschmidt. Additional music by Podington Bear and Lee Rosevere. Our theme music is by I am Robot and Proud. Art for this episode by Claire Merchlinsky. Story consulting by Ari Daniel. Engineering help from Sarah Fishman. Recording help from Alexa Lim. Thanks to Science Friday’s Danielle Dana, Christian Skotte, Brandon Echter, and Rachel Bouton.