Is Trump losing the thread as we head into 2026? And what's this—secular saint Oliver Sacks, the man who brought empathy to discussions of human weakness, made a lot of stuff up? Give a listen.
Weight-loss injections have become a major talking point, from Hollywood celebrities to TikTok influencers.
Originally developed to treat diabetes, these medications were later found to help people shed a lot of weight - a discovery that has rapidly expanded their global use. The World Health Organization has now released its first-ever guidance on prescribing them for obesity.
South Africa recently became the first country in Africa to formally approve one version of these drugs for weight loss, and access is slowly spreading across the continent.
We follow a Kenyan woman’s experience using the injections and we hear from a South African doctor who explains how they work - and what the latest medical research reveals so far.
According to the UN's humanitarian affairs agency, more than 800,000 displaced Gazans could be affected by flooding, as a winter storm surges along the coast. Most of them are living in tents.
Also in the programme: we meet the man who smuggled opposition leader Maria Corina Machado out of Venezuela; and Clair Obscur Expedition 33 is the clear winner in the world's top gaming awards, so why has a French arthouse creation proved such a hit?
(Photo: Displaced Palestinians ride a donkey-drawn cart on a flooded street in Gaza City, December 12, 2025. Credit: Reuters/Mahmoud Issa)
Inflation does more than just force up prices. It destroys the wealth-producing process, especially with young people who are prevented from acquiring the same kinds of assets earlier generations procured. The result is inter-generational conflict.
It’s the most wonderful time of the year — and with that, the obligatory office holiday party. Thing is, some choices around holiday parties can tell a story of how a company is doing. Who's there? Who's chatting together or sticking to a corner? What food and drink are being served? Today, we'll help you read the room. But first, most regional Federal Reserve bank presidents have been reappointed, despite some Trump administration proposals to exert greater control over the Fed's regional banks.
Cascades of rain flood the Pacific Northwest. Trump turns up the heat on Venezuela. It's a day in court for fired Michigan Coach Sherrone Moore. CBS News Correspondent Steve Kathan has those stories and more on the World News Roundup podcast.
From the BBC World Service: Reddit has filed a lawsuit calling for Australia's social media ban for children under 16 to be declared invalid. The text-based forum is one of 10 online platforms covered by the ban, which came into force this week. And later in the program, we head to Peru, where conflicts are brewing over how money from Machu Picchu tickets is being spent and whether it's benefiting tourists and locals.
Ukraine’s President Volodymyr Zelenskyy says he’s willing to hold elections if the US and other allies help ensure security. Is that a promise Trump can make as he pushes Ukraine to surrender territory to Russia? Also, Kilmar Abrego Garcia, a man illegally deported by the Trump administration in March and eventually returned, is now free from immigration custody. Plus, Republicans in Indiana have rejected a redistricting proposal. President Trump successfully pushed other states to redraw their congressional maps to help Republicans win next year’s midterm elections, so why did Indiana’s Republicans break with the president?
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Today’s episode of Up First was edited by Kate Bartlett, Anna Yukhananov, Larry Kaplow and Alice Woelfle.
It was produced by Ziad Buchh, Nia Dumas and Christopher Thomas.
We get engineering support from Stacey Abbott. Our technical director is Carleigh Strange
Plus: OpenAI rolls out a new version of ChatGPT in a bid to move ahead of competition from Google and Anthropic. And Lulelemon’s CEO plans to step down following a pressure campaign from the company’s outspoken founder. Luke Vargas hosts.