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Talk Python To Me - #533: Web Frameworks in Prod by Their Creators

Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in production. Deployment patterns, async gotchas, servers, scaling, and the stuff you only learn at 2 a.m. when the pager goes off. For Django, we have Carlton Gibson and Jeff Triplet. For Flask, we have David Lord and Phil Jones, and on team Litestar we have Janek Nouvertné and Cody Fincher, and finally Sebastián Ramírez from FastAPI is here. Let’s jump in.

Episode sponsors

Talk Python Courses
Python in Production

Links from the show

Carlton Gibson - Django: github.com
Sebastian Ramirez - FastAPI: github.com
David Lord - Flask: davidism.com
Phil Jones - Flask and Quartz(async): pgjones.dev
Yanik Nouvertne - LiteStar: github.com
Cody Fincher - LiteStar: github.com
Jeff Triplett - Django: jefftriplett.com

Django: www.djangoproject.com
Flask: flask.palletsprojects.com
Quart: quart.palletsprojects.com
Litestar: litestar.dev
FastAPI: fastapi.tiangolo.com
Coolify: coolify.io
ASGI: asgi.readthedocs.io
WSGI (PEP 3333): peps.python.org
Granian: github.com
Hypercorn: github.com
uvicorn: uvicorn.dev
Gunicorn: gunicorn.org
Hypercorn: hypercorn.readthedocs.io
Daphne: github.com
Nginx: nginx.org
Docker: www.docker.com
Kubernetes: kubernetes.io
PostgreSQL: www.postgresql.org
SQLite: www.sqlite.org
Celery: docs.celeryq.dev
SQLAlchemy: www.sqlalchemy.org
Django REST framework: www.django-rest-framework.org
Jinja: jinja.palletsprojects.com
Click: click.palletsprojects.com
HTMX: htmx.org
Server-Sent Events (SSE): developer.mozilla.org
WebSockets (RFC 6455): www.rfc-editor.org
HTTP/2 (RFC 9113): www.rfc-editor.org
HTTP/3 (RFC 9114): www.rfc-editor.org
uv: docs.astral.sh
Amazon Web Services (AWS): aws.amazon.com
Microsoft Azure: azure.microsoft.com
Google Cloud Run: cloud.google.com
Amazon ECS: aws.amazon.com
AlloyDB for PostgreSQL: cloud.google.com
Fly.io: fly.io
Render: render.com
Cloudflare: www.cloudflare.com
Fastly: www.fastly.com

Watch this episode on YouTube: youtube.com
Episode #533 deep-dive: talkpython.fm/533
Episode transcripts: talkpython.fm

Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython

Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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Short Wave - Did Earth’s Water Come From Space?

Choose your fighter for the origin of water on Earth! Was it always here or did it come to this planet from somewhere else in space? And, either way, what does this mean for other water worlds in our galaxy? To find out, we talk with Michael Wong, an astrobiologist and planetary scientist at Carnegie Science. He gets into scientists’ strongest candidates for the ways water could have come to our planet many, many years ago – including whether it could have been made here. Buckle up: This is a hot debate in astrobiology right now.

If you enjoyed this episode, check out our Space Camp series and our episode on whether life started on the ocean floor..

Interested in more space science and more unresolved hypotheses about how the universe came to be how it is today? Email us your question at shortwave@npr.org.

Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

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What Next | Daily News and Analysis - Don’t Call It a Regime Change

The Trump administration has a handful of answers to the question “Why did the United States pluck Nicolás Maduro from Venezuela?”—it was for narcoterrorism, or payback, or just oil. They’re even less clear about what’s going to happen with the country now.

Guest: Shane Harris, staff writer covering national security and intelligence for the Atlantic. 

Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.

Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther.



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NPR's Book of the Day - ‘Russ & Daughters’ cookbook documents a century-old New York City establishment

Russ & Daughters opened in 1914 and is one of the last remaining “appetizing stores” in New York City. The shop – which the owners say is not a deli – is famous for its bagels and lox, among other classic Jewish foods. Now, the Russ family is out with a cookbook that includes history, recipes and musings from the last century. In today’s episode, NPR’s Scott Simon visits Russ & Daughters, where he finds the shop brimming with smoked salmon, whitefish salad, chubs, trout, sable, sturgeon and more.

To listen to Book of the Day sponsor-free and support NPR's book coverage, sign up for Book of the Day+ at plus.npr.org/bookoftheday

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The Best One Yet - 🔮 “The Predictions Pod” — SpaceX’s Olympics, Starbucks’ Library, OpenAI’s company town.

#1. SpaceX’s Olympics


#2. Starbucks’ Library


#3. OpenAI’s company town


To kick off 2026, we whipped up our 7th annual “3 big business wishes” for the coming year. These ain’t *just* predictions — they’re wild wishes that if you think about it, make a ton of sense. Predictions sprinkled with razzle dazzle & sprinkle dinkle.


Hit us up @tboypod to let us know what you think of these predictions… and to let us know yours.


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About Us: The daily pop-biz news show making today’s top stories your business. Formerly known as Robinhood Snacks, The Best One Yet is hosted by Jack Crivici-Kramer & Nick Martell.



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The Government Huddle with Brian Chidester - 200: The One with the Former Obama Federal CIO

Tony Scott, former Federal Chief Information Officer under President Barack Obama and current President & CEO of Intrusion joins the show to give a candid, inside look at how the CIO role has evolved across government and industry—from back-office IT leadership to becoming a critical connector across mission, policy, technology, and organizational strategy. Tony reflects on his time overseeing an $85B federal IT portfolio, the challenges and urgency of modernizing aging systems, and the events surrounding the OPM breach that reshaped federal cybersecurity. 

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Global News Podcast - US sends warning to Venezuela’s new leader

The US has warned the new interim leader of Venezuela to do as it says - or face the consequences. Donald Trump says if Delcy Rodriguez "doesn’t do what’s right, she's going to pay a very big price". The ousted Venezuelan president, Nicolas Maduro, is due to appear in court in New York. Also in this podcast, Denmark's prime minister has told Donald Trump to "stop threats" about taking over Greenland. Police in Switzerland say they have now identified all forty victims of the New Year's Day fire in a bar in the ski resort of Crans-Montana. Iran's government has announced that it will begin paying a new monthly allowance to every citizen. The President of Nigeria, Bola Tinubu, has markedly increased his defence budget for 2026. The movie Avatar: Fire and Ash has made more than a billion dollars at the global box office.

The Global News Podcast brings you the breaking news you need to hear, as it happens. Listen for the latest headlines and current affairs from around the world. Politics, economics, climate, business, technology, health – we cover it all with expert analysis and insight. Get the news that matters, delivered twice a day on weekdays and daily at weekends, plus special bonus episodes reacting to urgent breaking stories. Follow or subscribe now and never miss a moment. Get in touch: globalpodcast@bbc.co.uk