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Short Wave - How Well Does A New Alzheimer’s Drug Work For Those Most At Risk?

A new drug for Alzheimer's disease, called lecanemab, got a lot of attention earlier this year for getting fast-tracked approval based on a clinical trial that included nearly 1,800 people. It was the most diverse trial for an Alzheimer's treatment to date, but still not enough to definitively say if the drug is effective for Black people. "[In] the world's most diverse Alzheimer's trial, a giant trial of 1,800 people that lasted for a much longer time than most trials did, we're still not sure that all of the groups that are at highest risk of Alzheimer's disease actually see any kind of benefit," says Dr. Jonathan Jackson, Assistant Professor of Neurology at Harvard Medical School.

On today's episode, Jonathan and Short Wave co-host Emily Kwong delve into how drug developers can overlook those hardest hit by the disease they're trying to treat.

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NPR's Book of the Day - Margaret Atwood ponders aging, fantasy and George Orwell in ‘Old Babes in the Wood’

Margaret Atwood has been writing for a long time – and as she tells NPR's Leila Fadel, the world looks very different today than it did when she started. Her new collection of short stories, Old Babes in the Wood, provides different approaches to the passing of time. There's a couple that's facing the realities of aging; there's a conversation with George Orwell, who Atwood says drastically changed her life; and there's even a parallel reality to the author's 1985 dystopian novel, The Handmaid's Tale, where men are the ones being controlled.
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It Could Happen Here - Operation Breakwater and Israel’s Far-Right Government

Shereen recaps some events in Palestine in 2022 that led to it being the deadliest year in the West Bank in decades. She also discusses Israel’s far-right government and the recently-appointed ultranationalist ministers who will only take it further in that direction.

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Motley Fool Money - Michael Lewis on Stock Market Overconfidence and Revisiting Moneyball

One sign of a true expert is they often say “I don’t know”.

Best-selling author Michael Lewis wrote classics like The Big Short, Liar's Poker, and Moneyball. He also hosts the podcast Against The Rules. Chris Hill talked with Lewis last year for an episode we published on May 20, 2022. Due to time constraints we had to leave some parts of the conversation out of that episode, so we're bringing them to you now! Hill and Lewis discuss: - Unintended consequences of Moneyball - Why single men fare worse in the stock market - How Iceland responded to the Great Recession - How to spot true experts

"Boys Will Be Boys" paper: https://faculty.haas.berkeley.edu/odean/papers/gender/BoysWillBeBoys.pdf

Host: Chris Hill Guest: Michael Lewis Producer: Ricky Mulvey Engineer: Dan Boyd

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Unexpected Elements - Human genome editing: Promise and Peril

We meet experts at the Human Genome Editing Summit in London, seeking to cure genetic disease and ensure that it is safe and available to all.

Roland Pease hears from Victoria Gray, the first person to be cured of the debilitating and life-shortening disease sickle cell anaemia by gene editing, and from the scientists making it possible.

Also, the prospect of work to attempt gene rescue in fetuses before they are born. But the technology is expensive and complex. The question troubling the participants is to ensure people across the world can benefit from it, not just the rich and privileged.

And what are the limitations of gene editing? Can it be made more effective, safer? And what of gene edits that will be inherited by future generations?

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CoinDesk Podcast Network - BREAKDOWN: We Pushed Semiconductors Offshore; Are We Doing the Same to Crypto?

Now, decades later, we're reviving semiconductor manufacturing with hundreds of millions of dollars.

On this week’s Long Reads Sunday, NLW reads:

Semiconductors: A Cautionary Tale by Sheila Warren

The SEC’s Other Option by TuongVy Le 

SEC Bitcoin ETF Dissent - Commissioner Hester Peirce and Commissioner Mark Uyeda

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“The Breakdown” is written, produced and narrated by Nathaniel Whittemore aka NLW, with editing by Michele Musso and research by Scott Hill. Jared Schwartz is our executive producer and our theme music is “Countdown” by Neon Beach. Music behind our sponsor today is “Foothill Blvd” by Sam Barsh. Image credit: Malte Mueller/ Getty Images, modified by CoinDesk. 

Join the discussion at discord.gg/VrKRrfKCz8.


Join the most important conversation in crypto and Web3 at Consensus 2023, happening April 26-28 in Austin, Texas. Come and immerse yourself in all that Web3, crypto, blockchain and the metaverse have to offer. Use code BREAKDOWN to get 15% off your pass. Visit consensus.coindesk.com.

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Everything Everywhere Daily - The Panama Canal

Every since the lands of the New World were mapped, people dreamt of creating a canal through Central America to connect the Atlantic and Pacific Oceans. 

For almost 500 years, that dream was just that. A dream. Creating such a canal would require one of the greatest engineering projects in human history. 

It was finally achieved in the early 20th century with an enormous amount of machinery, money, human lives, and a whole lot of political arm-twisting. 

Learn more about the Panama Canal and how it came to be on this episode of Everything Everywhere Daily.


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Associate Producers: Peter Bennett & Thor Thomsen

 

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