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Talk Python To Me - #524: 38 things Python developers should learn in 2025

Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In this episode, we count down 38 things to learn this year: free-threaded CPython, uv for packaging, Docker and Compose, Kubernetes with Tilt, DuckDB and Arrow, PyScript at the edge, plus MCP for sane AI workflows. Expect practical wins and migration paths. No buzzword bingo, just what pays off in real apps. Join me along with Peter Wang and Calvin Hendrix-Parker for a fun, fast-moving conversation.

Episode sponsors

Seer: AI Debugging, Code TALKPYTHON
Agntcy
Talk Python Courses

Links from the show

Calvin Hendryx-Parker: github.com/calvinhp
Peter on BSky: @wang.social

Free-Threaded Wheels: hugovk.github.io
Tilt: tilt.dev
The Five Demons of Python Packaging That Fuel Our ...: youtube.com
Talos Linux: talos.dev
Docker: Accelerated Container Application Development: docker.com
Scaf - Six Feet Up: sixfeetup.com
BeeWare: beeware.org
PyScript: pyscript.net
Cursor: The best way to code with AI: cursor.com
Cline - AI Coding, Open Source and Uncompromised: cline.bot

Watch this episode on YouTube: youtube.com
Episode #524 deep-dive: talkpython.fm/524
Episode transcripts: talkpython.fm

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In God We Lust - Listen now: Scamfluencers | The Pharmacist Femme Fatale

Natalie Cochran seemed like she had it all: a good job as a pharmacist, a loving husband, and two kids. But then she quit her job to become a government contractor and started raking in dough, or so she claimed. Behind the scenes, Natalie was running a classic Ponzi scheme, scamming friends and family with fake contracts, fake government emails, and even fake cancer. But when the walls start closing in, lies alone won’t be enough to save her… These are the stories of the world’s most insidious Scamfluencers. And we are their prey. Every week on Scamfluencers, join co-hosts Scaachi Koul and Sarah Hagi as they unpack epic stories of deception from the worlds of social media, fashion, finance, health, and wellness. These influencers claim to be everything from charismatic healers to trusted financial insiders to experts in dating. They cast spells over millions. Why do we believe them, and how does our culture allow them to thrive? Listen now: Wondery.fm/SCAM

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Strict Scrutiny - Will the Voting Rights Act Survive SCOTUS?

Leah, Kate, and Melissa break down last week’s agonizing two-and-a-half-hour oral argument in Louisiana v. Callais, a case that could see the already weakened Voting Rights Act gutted even further. They highlight the themes that emerged and dig into the case’s broader context with Sam Spital, Associate Director-Counsel at the Legal Defense Fund, then recap the week’s other arguments and the latest legal news. Finally, Leah talks with Joyce Vance about her new book, Giving Up Is Unforgivable: A Manual for Keeping a Democracy.

Favorite things:

Order your copy of Leah's book, Lawless: How the Supreme Court Runs on Conservative Grievance, Fringe Theories, and Bad Vibes

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What A Day - Over 7 Million Americans Protested Against Trump

Millions of Americans were in the streets over the weekend, rallying against President Donald Trump and his administration's latest authoritarian escalations. Organizers for the 'No Kings' protests said more than 7 million people turned out to more than 2,700 pro-democracy rallies across the country. Republicans tried their best to demonize the protesters saying the "hate America" demonstrations would be filled with radicals and violence. But, as it turns out, the protests were almost entirely peaceful. Chicago, Illinois, a focal point for the administration's crackdown on immigration, was just one of the cities that saw people gather in solidarity against Trump. So to talk more about the latest regarding Immigration and Customs Enforcement, the back and forth on National Guard deployment, and what's really happening on the ground there, we spoke with Monica Eng. She covers Chicago for Axios.

And in headlines, the Israel-Hamas ceasefire faces its first major test, Trump says he's ending financial aid to one of the country's closest Latin America allies, and the government shutdown stretches into a new week.

Show Notes:


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The NewsWorthy - Ceasefire Tested, Louvre Daytime Heist & Happy Diwali  – Monday, October 20, 2025

The news to know for Monday, October 20, 2025!

We’ll update you on the cease-fire in Gaza after the worst day of violence since President Trump declared peace in the Middle East.

Also, why President Trump released former Congressman George Santos from prison.

And how the Louvre was robbed in just seven minutes—in broad daylight.

Plus: why one British royal is giving up his titles, what new research shows about COVID-19 vaccines and cancer, and how Taylor Swift sparked a windfall for sea otters.

Those stories and even more news to know in about 10 minutes! 

 

Join us every Mon-Fri for more daily news roundups! 

See sources: https://www.theNewsWorthy.com/shownotes

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The Best One Yet - 🌴 “Date Maxxing” — Medjool Dates’ surge. Apple’s F1 fashion. Ramp’s ‘The Office’ strategy. +Worst Tipping City

Apple snagged the TV rights to Formula1… Because racing is now a luxury fashion product.

Ramp just hired the cast from ‘The Office’... and got the receipts on your most-expensed meal.

Date-maxxing is viral… Medjool date sales hit all-time highs because it’s the 1 fruit winning from Climate Change.

Plus, we found the worst-tipping city in America (this one’s awkward)...


$AAPL


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Ologies with Alie Ward - Bonus Episode: COCKROACH MILK with Joshua Benoit and Sinead English

Cockroach milk for Spooktober. STAY HERE. Don’t tell me you like haunted houses and slasher films but can’t listen to a lovely conversation about how cockroaches make milk to feed their young. It’s one of the most nutritious substances on Earth, and I own some. Sort of. Coem along for a brief and enthralling discussion from two researchers, Dr. Joshua Benoit and Dr. Sinead English, all about why and how some insects give live birth and nurse their young. What does it taste like? Will we replicate it for barista use? And why didn’t I get to eat any on TV? 

Watch Alie with bugs on her Tonight Show segment

Blattodeology (COCKROACHES) episode with Dr. Dominic Evangelista

Learn about Dr. Josh Benoit’s lab and Dr. Sinead English’s lab

More cockroach sources and links

Other episodes you may enjoy: Spooktober: Topics to Startle and Love, Entomology (INSECTS), Mantodeology (PRAYING MANTISES), Odonatology (DRAGONFLIES), Discard Anthropology (GARBAGE), Forest Entomology (CREEPY CRAWLIES), Disgustology (REPULSION TO GROSS STUFF), Fearology (FEAR), Entomophagy Anthropology (EATING BUGS), Speleology (CAVES)

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Produced by Mercedes Maitland of Maitland Audio Productions

Editing by Mercedes Maitland and Jake Chaffee

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Scheduling Producer: Noel Dilworth

Transcripts by Aveline Malek 

Website by Kelly R. Dwyer

Theme song by Nick Thorburn


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The Indicator from Planet Money - Why are veterinarian bills getting so ruff on the wallet?

Since 2020, the cost of veterinary care has increased about 40%—almost twice the rate of inflation. As a result, many pet owners say they've skipped necessary vet care. So, what's going on here? A veterinarian, and a lesser-known economic theory, have some answers. 

Related episodes: 
The Vet Clinic Chow Down 
What Do Private Equity Firms Actually Do?

For sponsor-free episodes of The Indicator from Planet Money, subscribe to Planet Money+ via Apple Podcasts or at plus.npr.org. Fact-checking by Sierra Juarez. Music by Drop Electric. Find us: TikTok, Instagram, Facebook, Newsletter.  

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Short Wave - Should Scientists Genetically Engineer Wild Species?

Some scientists looking to preserve vulnerable species have turned to a controversial technique: synthetic biology. This catchall term often means genetic engineering – introducing new genes to an organism. And a recent narrow vote by the International Union for Conservation of Nature on using the technology shows how divided scientists are on the issue of releasing genetically altered species. Science correspondent Nate Rott wades into the debate with us and reveals whether or not the Union voted to place a moratorium on releasing gene-edited species.


Read more of Nate’s reporting on the topic.  


Interested in more science debates? Email us your question at shortwave@npr.org.


Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

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What Next | Daily News and Analysis - Are Democrats Already Fumbling a Win?

Off-cycle elections generally favor the party that isn’t in the White House. And with a large voting bloc of federal employees, Virginia Democrats were feeling good about the upcoming elections for governor and attorney general. Then texts from their AG candidate hit the news.

Guest: Eva McKend, correspondent covering national politics for CNN.

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Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther.

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